CDK8 antibody
Rabbit anti Human CDK8
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- CDK8
Rabbit anti Human CDK8 antibody recognizes cell division protein kinase 8, also known as cell division protein kinase 8 or mediator complex subunit CDK8. CDK8 is a 53 kDa is a member of the cyclin-dependent protein kinase (CDK) family involved in transcriptional regulation via interaction with the mediator complex (Tassan et al. 1995). CDK8 regulates the activity of several transcription factors via its kinase activity, including STAT1 (Bancerek et al. 2013). CDK8 is also able to inhibit transcriptional activation by influencing the turnover of subunits in the mediator complex tail module and mediating the binding of RNA polymerase II to the mediator complex (Tsai et al. 2013). Expression of CDK8 may contribute to the development of a number of different types of cancer (Firestein et al. 2008, Donner et al. 2007). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human CDK8 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.035% Sodium Azide (NaN3)
30% Glycerol - Carrier Free
- Yes
- Immunogen
- A peptide within the C-terminal region of human CDK8
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Chromatin Immunoprecipitation | 10 µl per ChIP | ||
Western Blotting | 1/500 | 1/1500 |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml | Log in | |||
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Description | Sheep anti Rabbit IgG:RPE |
- UniProt
- P49336
- Entrez Gene
- CDK8
- GO Terms
- GO:0005515 protein binding
- GO:0004693 cyclin-dependent protein kinase activity
- GO:0005524 ATP binding
- GO:0006350 transcription
- GO:0006468 protein phosphorylation
- GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
- GO:0016592 mediator complex
- GO:0045449 regulation of transcription
AHP3032
160770If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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