Rabbit anti CD184/CXCR4 antibody recognizes CD184, also known as C-X-C chemokine receptor type 4 (CXCR4), LESTR or SDF-1 receptor.
CD184 is a member of the G-protein coupled receptor 1 family and a receptor for the chemokine SDF-1 (stromal cell-derived factor 1). CD184 also acts as a receptor for extracellular ubiquitin and as a coreceptor for HIV-1. CD184/CXCR4 is involved in multiple processes including chemotaxis, cell proliferation, survival and adhesion.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to CD184/CXCR4 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Synthetic human CD184/CXCR4 peptide
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
activation of MAPK activity
response to hypoxia
response to virus
integral to membrane
elevation of cytosolic calcium ion concentration
cytoplasmic membrane-bounded vesicle
C-C chemokine receptor activity
C-X-C chemokine receptor activity
initiation of viral infection
entry into host cell
cell leading edge
ubiquitin protein ligase binding
myosin light chain binding
regulation of chemotaxis
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD184 / CXCR4 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti CD184/CXCR4 antibody detects a band of approximately 70 kDa in cell lysates and tissue lysates under reducing conditions
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
References for CD184 / CXCR4 antibody
Wu, W. et al. (2012) The bone marrow-expressed antimicrobial cationic peptide LL-37 enhances the responsiveness of hematopoietic stem progenitor cells to an SDF-1 gradient and accelerates their engraftment after transplantation.
Leukemia. 26 (4): 736-45.
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