CD184 / CXCR4 antibody
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WB P ResetRabbit anti CD184 / CXCR4
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- CD184 / CXCR4
Antibody Quality and 
Unrivaled 
| Rabbit anti CD184/CXCR4 antibody recognizes CD184, also known as C-X-C chemokine receptor type 4 (CXCR4), LESTR or SDF-1 receptor. CD184 is a member of the G-protein coupled receptor 1 family and a receptor for the chemokine SDF-1 (stromal cell-derived factor 1). CD184 also acts as a receptor for extracellular ubiquitin and as a coreceptor for HIV-1. CD184/CXCR4 is involved in multiple processes including chemotaxis, cell proliferation, survival and adhesion. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to CD184/CXCR4 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Synthetic human CD184/CXCR4 peptide
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/50 | 1/100 |
| Western Blotting | |
1/500 | 1/1000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti CD184/CXCR4 antibody detects a band of approximately 70 kDa in cell lysates and tissue lysates under reducing conditions
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| TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml | Log in | |||
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References for CD184 / CXCR4 antibody
-
Wu, W. et al. (2012) The bone marrow-expressed antimicrobial cationic peptide LL-37 enhances the responsiveness of hematopoietic stem progenitor cells to an SDF-1 gradient and accelerates their engraftment after transplantation.
Leukemia. 26 (4): 736-45.
- UniProt
- P61073
- Entrez Gene
- CXCR4
- GO Terms
- GO:0005886 plasma membrane
- GO:0000187 activation of MAPK activity
- GO:0001666 response to hypoxia
- GO:0003779 actin binding
- GO:0009615 response to virus
- GO:0006915 apoptosis
- GO:0016021 integral to membrane
- GO:0006954 inflammatory response
- GO:0007204 elevation of cytosolic calcium ion concentration
- View More GO Terms
- GO:0009986 cell surface
- GO:0015026 coreceptor activity
- GO:0016023 cytoplasmic membrane-bounded vesicle
- GO:0016493 C-C chemokine receptor activity
- GO:0016494 C-X-C chemokine receptor activity
- GO:0019059 initiation of viral infection
- GO:0030260 entry into host cell
- GO:0031252 cell leading edge
- GO:0031625 ubiquitin protein ligase binding
- GO:0032027 myosin light chain binding
- GO:0043130 ubiquitin binding
- GO:0050920 regulation of chemotaxis
View more products with CD184 specificity
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