Rabbit anti CD126/IL-6R antibody recognizes CD126/IL-6R, also known as interleukin-6 receptor subunit alpha. CD126/IL-6R is a member of the type I cytokine receptor family. CD126/IL-6R binds to IL-6, the IL-6/IL-6R complex then associates with two molecules of interleukin 6 signal transducer (IL6ST), leading to signaling via the JAK/STAT pathway.
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to CD126/IL-6R was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Recombinant human CD126/IL-6R
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
hepatic immune response
neutrophil mediated immunity
positive regulation of leukocyte chemotaxis
interleukin-6 receptor complex
defense response to Gram-positive bacterium
defense response to Gram-negative bacterium
positive regulation of activation of Janus kinase activity
basolateral plasma membrane
apical plasma membrane
regulation of apoptosis
endocrine pancreas development
negative regulation of interleukin-8 production
positive regulation of chemokine production
positive regulation of interleukin-6 production
negative regulation of collagen biosynthetic process
response to cytokine stimulus
positive regulation of tyrosine phosphorylation of Stat3 protein
protein homodimerization activity
positive regulation of MAPKKK cascade
positive regulation of osteoblast differentiation
positive regulation of anti-apoptosis
positive regulation of smooth muscle cell proliferation
interleukin-6-mediated signaling pathway
ciliary neurotrophic factor binding
ciliary neurotrophic factor-mediated signaling pathway
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD126/Il-6R antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti CD126/IL-6R antibody detects a band of approximately 52 kDa in cell lysates under reducing conditions
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Secondary Antibodies Available
Useful Reagents Available
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