BMP-2 antibody
Rabbit anti BMP-2 antibody recognizes bone morphogenetic protein 2 (BMP-2), also known as BMP-2A. BMP-2 is a member of the transforming growth factor (TGF)-beta protein family. BMP-2 is involved in osteoblast differentiation and the development of bone and cartilage.
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to BMP-2 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Recombinant human BMP-2
Storage Information
- Storage
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P12643
- Entrez Gene
- BMP2
- GO Terms
- GO:0001649 osteoblast differentiation
- GO:0001938 positive regulation of endothelial cell proliferation
- GO:0003130 BMP signaling pathway involved in heart induction
- GO:0005125 cytokine activity
- GO:0005160 transforming growth factor beta receptor binding
- GO:0005615 extracellular space
- GO:0040007 growth
- GO:0008083 growth factor activity
- GO:0008285 negative regulation of cell proliferation
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
- GO:0010922 positive regulation of phosphatase activity
- GO:0016362 activin receptor activity, type II
- GO:0016563 transcription activator activity
- GO:0016566 specific transcriptional repressor activity
- GO:0019211 phosphatase activator activity
- GO:0030501 positive regulation of bone mineralization
- GO:0035051 cardiac cell differentiation
- GO:0035630 bone mineralization involved in bone maturation
- GO:0043065 positive regulation of apoptosis
- GO:0045669 positive regulation of osteoblast differentiation
- GO:0045786 negative regulation of cell cycle
- GO:0046332 SMAD binding
- GO:0046982 protein heterodimerization activity
- GO:0051216 cartilage development
- GO:0060317 cardiac epithelial to mesenchymal transition
- GO:0060389 pathway-restricted SMAD protein phosphorylation
- GO:0060395 SMAD protein signal transduction
- GO:0061036 positive regulation of cartilage development
- GO:0070700 BMP receptor binding
- Regulatory
- For research purposes only
Applications of BMP-2 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin | 1/50 | 1/100 | |
| Western Blotting | 1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti BMP-2 antibody detects a band of approximately 44 kDa in HeLa cell lysate under reducing conditions
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
|
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| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
|
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| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
|
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| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
|
| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
|
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| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
|
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| Sheep anti Rabbit IgG:DyLight®488 | STAR36D488GA | F IF WB | 0.1 mg | ||
| Sheep anti Rabbit IgG:DyLight®680 | STAR36D680GA | F IF WB | 0.1 mg | ||
| Sheep anti Rabbit IgG:Dylight®800 | STAR36D800GA | F IF WB | 0.1 mg |
Useful Reagents Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml |
Fluorescent Spectraviewer
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