Rabbit anti BMP-2 antibody recognizes bone morphogenetic protein 2 (BMP-2), also known as BMP-2A. BMP-2 is a member of the transforming growth factor (TGF)-beta protein family. BMP-2 is involved in osteoblast differentiation and the development of bone and cartilage.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to BMP-2 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Recombinant human BMP-2
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
positive regulation of endothelial cell proliferation
BMP signaling pathway involved in heart induction
transforming growth factor beta receptor binding
growth factor activity
negative regulation of cell proliferation
positive regulation of gene-specific transcription from RNA polymerase II promoter
negative regulation of gene-specific transcription from RNA polymerase II promoter
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of phosphatase activity
activin receptor activity, type II
transcription activator activity
specific transcriptional repressor activity
phosphatase activator activity
positive regulation of bone mineralization
cardiac cell differentiation
bone mineralization involved in bone maturation
positive regulation of apoptosis
positive regulation of osteoblast differentiation
negative regulation of cell cycle
protein heterodimerization activity
cardiac epithelial to mesenchymal transition
pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
positive regulation of cartilage development
BMP receptor binding
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of BMP-2 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti BMP-2 antibody detects a band of approximately 44 kDa in HeLa cell lysate under reducing conditions
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Secondary Antibodies Available
Useful Reagents Available
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