BAX antibody

Rabbit anti BAX

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
BAX

Product Code Applications Pack Size List Price Your Price Qty
AHP2716
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SDS Safety Datasheet SDS
WB 50 µl loader
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Rabbit anti BAX antibody recognizes the Bcl-2-associated X protein (BAX) also known as Bcl-2 like protein 4. BAX together with BAK (BCL-2 antagonist or killer), another member of the Bcl-2 family, plays a key role in the intrinsic apoptosis pathway by inducing mitochondrial outer membrane permeabilization (MOMP) (Giansanti and Scovassi 2008). This event is aided by BID (BH3-interacting domain death agonist), which activates the two proteins and thereby facilitates the formation of homo- or heterodimers. Often in the literature, MOMP is regarded as the point of no return upon which a cell is committed to undergo apoptosis (Chipuk et al. 2006).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to BAX was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Synthetic human BAX peptide
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti BAX antibody detects a band of approximately 21 kDa in cell lysates under reducing conditions

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References for BAX antibody

  1. Giansanti, V. & Scovassi, A.I. (2008) Cell Death: A One-Way Journey to the Graveyard.
    The Open Biology Journal (1): 27-34.
  2. Chipuk, J.E. et al. (2006) Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario.
    Cell Death Differ. 13 (8): 1396-402.

UniProt
Q07812
Entrez Gene
BAX
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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