BAP1 antibody
Rabbit anti Human BAP1
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- BAP1
Antibody Quality and Performance Guarantee
| Rabbit anti Human BAP1 antibody recognizes BAP1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), also known as BRCA1-associated protein 1 or cerebral protein 6. BAP1 localizes to the nucleus where it acts as a deubiquitinase due to its ubiquitin carboxy-terminal hydrolase (UCH) domain (Jensen et al. 1998). BAP1 is a member of the polycomb-group proteins (PcGs). PcGs are a group of highly conserved transcriptional repressors required for long-term silencing of genes that regulate various processes including cell fate determination, and stem cell pluripotency (Gaytán de Ayala Alonso et al. 2007). BAP1 functions as a tumor suppressor and mutations in the BAP1 gene may be linked to the development of a number of different cancers including malignant mesothelioma (Cheung and Testa, 2017). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human BAP1 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.035% Sodium Azide (NaN3)
30% Glycerol - Carrier Free
- Yes
- Immunogen
- A peptide within the C-terminal region of human BAP1
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- Q92560
- Entrez Gene
- BAP1
- GO Terms
- GO:0005515 protein binding
- GO:0001558 regulation of cell growth
- GO:0003682 chromatin binding
- GO:0051726 regulation of cell cycle
- GO:0004221 ubiquitin thiolesterase activity
- GO:0004843 ubiquitin-specific protease activity
- GO:0005737 cytoplasm
- GO:0005730 nucleolus
- GO:0006511 ubiquitin-dependent protein catabolic process
- View More GO Terms
- GO:0008285 negative regulation of cell proliferation
- GO:0035517 PR-DUB complex
- GO:0035522 monoubiquitinated histone H2A deubiquitination
- GO:0071108 protein K48-linked deubiquitination
AHP3028
160753
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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