BAP1 antibody

Rabbit anti Human BAP1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
BAP1

Product Code Applications Pack Size List Price Your Price Qty
AHP3028
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 ml loader
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loader
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Rabbit anti Human BAP1 antibody recognizes BAP1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), also known as BRCA1-associated protein 1 or cerebral protein 6.

BAP1 localizes to the nucleus where it acts as a deubiquitinase due to its ubiquitin carboxy-terminal hydrolase (UCH) domain (Jensen et al. 1998). BAP1 is a member of the polycomb-group proteins (PcGs). PcGs are a group of highly conserved transcriptional repressors required for long-term silencing of genes that regulate various processes including cell fate determination, and stem cell pluripotency (Gaytán de Ayala Alonso et al. 2007). BAP1 functions as a tumor suppressor and mutations in the BAP1 gene may be linked to the development of a number of different cancers including malignant mesothelioma (Cheung and Testa, 2017).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human BAP1 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.035% Sodium Azide (NaN3)
30% Glycerol
Carrier Free
Yes
Immunogen
A peptide within the C-terminal region of human BAP1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
Q92560
Entrez Gene
BAP1
GO Terms
GO:0005515 protein binding
GO:0001558 regulation of cell growth
GO:0003682 chromatin binding
GO:0051726 regulation of cell cycle
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005737 cytoplasm
GO:0005730 nucleolus
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008285 negative regulation of cell proliferation
GO:0035517 PR-DUB complex
GO:0035522 monoubiquitinated histone H2A deubiquitination
GO:0071108 protein K48-linked deubiquitination
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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