5-HT7 Receptor antibody
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P ResetRabbit anti Human 5-HT7 Receptor (C-Terminal)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- 5-HT7 Receptor
- Region
- (C-TERMINAL)
Antibody Quality and 
Unrivaled 
| Rabbit anti Human 5-HT7 receptor antibodyrecognizes the C-terminal region of the serotonin (5-hydroxytryptamine, 5-HT) receptor 5-HT7, which belongs to the G-protein coupled receptor superfamily. Serotonin is a neurotransmitter and vasoactive amine which is thought to play a role in various cognitive and behavioural functions including pain, appetite, mood and sleep. Signalling through 5-HT7 has several effects, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and gastrointestinal tract. Signalling though 5-HT7 has also been shown to contribute to early T-cell activation. 5-HT7 has been implicated in depression, autism, and other neuropsychiatric disorders. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to 5-HT7 receptor (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide corresponding to the C-terminal regoin of human 5-HT7 receptor, conjugated to Keyhole Limpet Hemocyanin (KLH).
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin 1 |  |
10ug/ml |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Brain, cerebellum
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| Antigen Retrieval Buffer, pH8.0 | BUF025A | P | 500 ml | Log in | |||
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| Description | Antigen Retrieval Buffer, pH8.0 | ||||||
References for 5-HT7 Receptor antibody
-
Kobe, F. et al. (2012) 5-HT7R/G12 Signaling Regulates Neuronal Morphology and Function in an Age-Dependent Manner.
J Neurosci. 32: 2915-30. -
Renner, U. et al. (2012) Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking.
J Cell Sci. 125 (Pt 10): 2486-99.
Further Reading
-
León-Ponte, M. et al. (2007) Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor.
Blood. 109 (8): 3139-46.
- Synonyms
- HTR7
- RRID
- AB_906117
- UniProt
- P34969
- Entrez Gene
- HTR7
- GO Terms
- GO:0005515 protein binding
- GO:0004993 serotonin receptor activity
- GO:0005887 integral to plasma membrane
- GO:0007623 circadian rhythm
- GO:0008015 blood circulation
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