GFR Alpha 2 antibody

Rabbit anti GFR Alpha 2

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
GFR Alpha 2

Product Code Applications Pack Size List Price Your Price Qty
AHP479
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C WB 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Rabbit anti GFR alpha-2 antibody recognizes the cell surface receptor for neurturin, designated GFR alpha-2. Neurturin is a member of the GDNF family, and has an important role in the control of vertebrate neuron survival and differentiation. GRF alpha-2 is a ~52 kDa glycoprotein, and is a GPI-linked cell surface receptor.

Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
Human
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human GFR alpha-2 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide
Immunogen
Synthetic peptide from C-terminus of human GFR alpha-2.
Approx. Protein Concentrations
IgG concentration 1 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen
Western Blotting 1/1000
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

Description Product Code Applications Pack Size List Price Your Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
List Price Your Price
loader
Description Goat anti Rabbit IgG (Fc):Biotin
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
List Price Your Price
loader
Description Goat anti Rabbit IgG (Fc):FITC
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
List Price Your Price
loader
Description Goat anti Rabbit IgG (Fc):HRP
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
List Price Your Price
loader
Description Goat anti Rabbit IgG (H/L):HRP
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
List Price Your Price
loader
Description Sheep anti Rabbit IgG:FITC
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
List Price Your Price
loader
Description Sheep anti Rabbit IgG:RPE

Description Product Code Applications Pack Size List Price Your Price Quantity
TidyBlot Western Blot Detection Reagent:HRP STAR209P WB* 0.5 ml
List Price Your Price
Description TidyBlot Western Blot Detection Reagent:HRP

Further Reading

  1. Kotzbauer, P.T. et al. (1996) Neurturin, a relative of glial-cell-line-derived neurotrophic factor.
    Nature. 384 (6608): 467-70.
  2. Klein, R.D. et al. (1997) A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor.
    Nature. 387 (6634): 717-21.
  3. Buj-bello, A. et al. (1997) Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.
    Nature. 387 (6634): 721-4.
  4. GFRα Nomenclature Committee (1997) Nomenclature of GPI-linked receptors for the GDNF ligand family.
    Neuron 19: 485.

RRID
AB_2247568
UniProt
O00451
Entrez Gene
GFRA2
GO Terms
GO:0005886 plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0031225 anchored to membrane
GO:0016167 glial cell line-derived neurotrophic factor receptor activity
GO:0019898 extrinsic to membrane
Request a different product with this specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"