Clostridium difficile Toxin A antibody

Rabbit anti Clostridium difficile Toxin A

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Clostridium difficile Toxin A

Product Code Applications Pack Size List Price Your Price Qty
0100-0153
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 1 ml loader
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loader
Search for Batch Specific Datasheets

Rabbit anti Clostridium difficile toxin A antibody recognizes Clostridium difficile toxin A. Clostridium difficile is a gram-positive motile bacterium and the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density, and the administration of antibiotics.

Toxin A (TcdA) is a large exotoxin which is an essential virulence factor for C. difficile infection. TcdA has a molecular mass of ~308 kDa and is a glucosyltransferase, which irreversibly inactivates the Ras family of small GTPases to disrupt many important signalling pathways.

Target Species
Bacterial
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Synthetic peptide corresponding to the amino acids 2123 - 2132 of the native molecule conjugated to Keyhole limpet Haemocyanin.

Peptide sequence: CTIDGKKYYFN.
Approx. Protein Concentrations
IgG concentration 5.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

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References for Clostridium difficile Toxin A antibody

  1. Voth, D.E. & Ballard, J.D. (2005) Clostridium difficile toxins: mechanism of action and role in disease.
    Clin Microbiol Rev. 18 (2): 247-63.

RRID
AB_619372
UniProt
P16154
GO Terms
GO:0009405 pathogenesis