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Adiponectin antibody

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Anti Adiponectin (C-Terminal) Antibody thumbnail image 1 Anti Adiponectin (C-Terminal) Antibody thumbnail image 2 Anti Adiponectin (C-Terminal) Antibody thumbnail image 3
Anti Adiponectin (C-Terminal) Antibody gallery image 1
Western blot analysis of whole cell lysate from HL60 promyelocytic leukemia cells probed with Rabbit anti Human adiponectin (AHP1005) at 0.5(A), 1(B) and 2(C) ug/ml.
Anti Adiponectin (C-Terminal) Antibody gallery image 2
Immunohistochemical staining of formalin fixed, paraffin embedded rat brain with Rabbit anti Human adiponectin (AHP1005)
Anti Adiponectin (C-Terminal) Antibody gallery image 3
Immunocytochemical staining of HL60 cells with Rabbit anti Human adiponectin (AHP1005)

Rabbit anti Adiponectin (C-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Adiponectin
Region
(C-TERMINAL)

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Product Code Applications Pack Size List Price Your Price Qty
AHP1005
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F P * WB 0.1 mg loader
List Price Your Price
loader

Rabbit anti Human adiponectin antibody recognizes an epitope within the C-terminal region (CT) of the 244 amino acid protein adiponectin (also known as Acrp30), a major adipokine secreted into the bloodstream from adipose tissue to modulate metabolism, including glucose regulation and fatty acid catabolism.

Unlike most other adipokines, Adiponectin is secreted exclusively by differentiating adipocytes at reduced levels during obesity. The serum level of Adiponectin is inversely correlated with BMI (body mass index) of an individual, and has an anti-inflammatory action, playing an important role in type II diabetes (insulin sensitivity) and atherosclerosis.

Species Cross-Reactivity
Target SpeciesCross Reactivity
Human
Rat
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to Human Adiponectin (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide (NaN3)
Immunogen
A 15 amino acid peptide located near human Adiponectin carboxy-terminus.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry
Immunohistology - Paraffin 1 10ug/ml
Western Blotting 1 2ug/ml
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Rat brain.
Western Blotting
AHP1005 detects a band of approximately 26.4kDa in human HL60 cell lysates

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References for Adiponectin antibody

  1. Su, S.C. et al. (2021) Growth arrest-specific 6 modulates adiponectin expression and insulin resistance in adipose tissue.
    J Diabetes Investig. 12 (4): 485-492.

Further Reading

  1. Wong, G.W. et al. (2004) A family of Acrp30/adiponectin structural and functional paralogs.
    Proc Natl Acad Sci U S A. 101 (28): 10302-7.
  2. Lihn, A.S. et al. (2005) Adiponectin: action, regulation and association to insulin sensitivity.
    Obes Rev. 6 (1): 13-21.
  3. Trayhurn, P. & Wood, I.S. (2005) Signalling role of adipose tissue: adipokines and inflammation in obesity.
    Biochem Soc Trans. 33 (Pt 5): 1078-81.

Synonyms
ADIPOQ
RRID
AB_609554
UniProt
Q15848
Entrez Gene
ADIPOQ
GO Terms
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0005615 extracellular space
GO:0006006 glucose metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006635 fatty acid beta-oxidation
GO:0009749 response to glucose stimulus
GO:0010739 positive regulation of protein kinase A signaling cascade
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010875 positive regulation of cholesterol efflux
GO:0046326 positive regulation of glucose import
GO:0030853 negative regulation of granulocyte differentiation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033034 positive regulation of myeloid cell apoptosis
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0034383 low-density lipoprotein particle clearance
GO:0034612 response to tumor necrosis factor
GO:0042593 glucose homeostasis
GO:0042803 protein homodimerization activity
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043499 eukaryotic cell surface binding
GO:0045599 negative regulation of fat cell differentiation
GO:0045650 negative regulation of macrophage differentiation
GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045721 negative regulation of gluconeogenesis
GO:0045923 positive regulation of fatty acid metabolic process
GO:0050728 negative regulation of inflammatory response
GO:0050765 negative regulation of phagocytosis

AHP1005

150522 156214 159142 162118 165691

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