Risankizumab antibody | AbD59005ia




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E ResetHuman anti Risankizumab
- Product Type
- Monoclonal Antibody
- Clone
- AbD59005ia
- Isotype
- IgG1
- Specificity
- Risankizumab
Human Anti-Risankizumab Antibody, clone AbD59005ia is a paratope specific, inhibitory, anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody drug risankizumab, and its biosimilar products. It does not recognize the drug target, human Interleukin 23 (IL-23), nor risankizumab in complex with IL-23. This antibody can be used to measure free risankizumab levels in serum from patients. Clone AbD59005ia is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or calibrator in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 5nM and is one of the three antibodies offered for ADA assays. Antibody HCA414 has an affinity of 0.1nM and HCA416 has an affinity of 8nM. Risankizumab (trade name Skyrizi) is a humanized monoclonal antibody of the IgG1/kappa isotype that suppresses the inflammatory effects of interleukin-23 by selectively targeting its unique p19 subunit, subsequently inhibiting IL-23 binding to its receptor and the signaling responsible for the release of pro-inflammatory cytokines and chemokines. Risankizumab is indicated as an interleukin-23 antagonist in the treatment of plaque psoriasis, psoriatic arthritis and Crohn's disease in adults. |
- Product Form
- Human IgG1 antibody (lambda light chain) selected from the HuCAL phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Source
- HKB-11
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Risankizumab
- Affinity
- The monovalent intrinsic affinity of Human anti-Risankisumab Antibody, clone AbD59005ia was measured as KD = 5 nM by real time, label-free molecular interaction analysis on immobilized risankizumab.
- Approx. Protein Concentrations
- Antibody concentration 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
Skyrizi is a registered trademark of AbbVie Biotechnology Ltd. - Licensed Use
- For in vitro. research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
- Technical Advice
- Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
- ELISA
- Clone AbD59005ia can be used in indirect ELISA to detect risankizumab. It can also be used as a surrogate positive control or a calibrator in an anti-drug antibody (ADA) assay, together with HCA414 and HCA416.
Protocol: ADA bridging ELISA
- Synonyms
- Skyrizi
HCA415

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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