Ocrelizumab antibody | AbD50641ia
Human anti Ocrelizumab
- Product Type
- Monoclonal Antibody
- Clone
- AbD50641ia
- Isotype
- IgG1
- Specificity
- Ocrelizumab
Human Anti-Ocrelizumab Antibody, clone AbD50641ia is a paratope specific, inhibitory, anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody drug ocrelizumab and its biosimilar products. Consequently, this antibody can be used to measure free ocrelizumab levels in serum from patients. Clone AbD50641ia (HCA400) is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a positive control or calibrator in an anti-drug antibody (ADA) assay. This clone is also available in a monovalent Fab antibody format under product code TZA044 which has a SpyTag incorporated for conversion by the user into alternative antibody formats using any of the SpyCatchers available in our catalog. View a summary of all SpyCatcher products This Anti-Ocrelizumab Antibody cross-reacts with the drug rituximab (Rituxan). Ocrelizumab is the humanized form of rituximab. There are changes in at least one of the CDRs and it contains Fc modification. Ocrelizumab (trade name Ocrevus) is a monoclonal IgG1/kappa antibody (VH3/κ1). In vitro, it binds to CD20 cell surface molecules on target cells thereby inducing immune effector mechanisms such as antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and apoptosis. In vivo, ocrelizumab selectively and effectively depletes CD20+ B cells. Hence, it is an immunosuppressive drug. Ocrelizumab is used to treat primary progressive multiple sclerosis and relapsing forms of multiple sclerosis in adults (including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease). View a summary of all anti-ocrelizumab antibodies |
- Product Form
- Human IgG1 antibody (lambda light chain) selected from Bio-Rad’s human antibody phage display libraries. This antibody is supplied as a liquid.
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Source
- HKB-11
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Ocrelizumab
- Affinity
- The monovalent intrinsic affinity of Human anti-Ocrelizumab Antibody, clone AbD50641ia was measured as KD<0.001 nM by real time, label-free molecular interaction analysis on immobilized ocrelizumab.
- Approx. Protein Concentrations
- Antibody concentration 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
Ocrevus is a registered trademark of Genentech/ Roche and Biogen.
Rituxan is a registered trademark of Genentech and Biogen. - Licensed Use
- For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA |
- Technical Advice
- Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
- ELISA
- This product may be used to develop and calibrate immune response assays to measure the anti-drug antibody (ADA) response in patient sera together with HCA399 and HCA401.
Protocol: ADA bridging ELISA
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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Hispec Assay Diluent | BUF049A | E IY | 50 ml | Log in | |||
List Price | Your Price | ||||||
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Description | Hispec Assay Diluent | ||||||
Human anti Ocrelizumab | HCA399 | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Ocrelizumab | ||||||
Human anti Ocrelizumab | HCA401 | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Ocrelizumab | ||||||
LYNX Rapid HRP Antibody Conjugation Kit | LNK002P | CJ | 3 Conjugations For 400µg Antibody | Log in | |||
List Price | Your Price | ||||||
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Description | LYNX Rapid HRP Antibody Conjugation Kit | ||||||
Human anti Ocrelizumab | TZA044 | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Ocrelizumab | ||||||
Human anti Ocrelizumab | TZA045 | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Ocrelizumab | ||||||
Human anti Ocrelizumab:HRP | TZA045P | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Ocrelizumab:HRP |
- Synonyms
- Ocrevus
HCA400
166855If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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