Ocrelizumab antibody | AbD47395ia




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E FN ResetHuman anti Ocrelizumab
- Product Type
- Monoclonal Antibody
- Clone
- AbD47395ia
- Isotype
- IgG1
- Specificity
- Ocrelizumab
Human Anti-Ocrelizumab Antibody, clone AbD47395ia is a paratope specific, inhibitory, anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody drug ocrelizumab, and its biosimilar products. It does not recognize the drug target, the B cell surface marker CD20, nor ocrelizumab in complex with CD20. This antibody can be used to measure free ocrelizumab levels in serum from patients. Clone AbD47395ia (HCA399) is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or calibrator in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 25.6nM and is one of the three antibodies offered for ADA assays. Antibody HCA400 has an affinity of <0.001nM and HCA401 has an affinity of 0.7nM. Ocrelizumab (trade name Ocrevus) is a humanized monoclonal antibody of the IgG1/kappa isotype developed from the monoclonal antibody drug rituximab. Ocrelizumab targets the B cell surface marker CD20. Binding of the drug to its target triggers cell death through a number of mechanisms, including apoptosis, complement activation and cell-mediated cytotoxicity. In vivo, ocrelizumab selectively and effectively depletes CD20 expressing B cells, hence acting as an immunosuppressive drug. Ocrelizumab is used in the treatment of primary progressive multiple sclerosis and relapsing forms of multiple sclerosis in adults. View a summary of all anti-ocrelizumab antibodies. |
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- Product Form
- Human IgG1 antibody (lambda light chain) selected from Bio-Rad’s human antibody phage display libraries. This antibody is supplied as a liquid.
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Source
- HKB-11
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Ocrelizumab
- Affinity
- The monovalent intrinsic affinity of Human anti-Ocrelizumab Antibody, clone AbD47395ia was measured as KD = 25.6 nM by real time, label-free molecular interaction analysis on immobilized ocrelizumab.
- Approx. Protein Concentrations
- Antibody concentration 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
Ocrevus is a registered trademark of Genentech/ Roche and Biogen.
Rituxan is a registered trademark of Genentech and Biogen. - Licensed Use
- For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.
When ready to use, thaw and aliquot the sample as needed. Store aliquots at -70°C, if available, otherwise store at -20°C. It is not recommended to keep aliquots at 4°C for more than one week.
Application Name | Verified | Min Dilution | Max Dilution |
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ELISA | ![]() |
- Technical Advice
- Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
- ELISA
- This product may be used to develop and calibrate immune response assays to measure the anti-drug antibody (ADA) response in patient sera together with HCA400 and HCA401.
Protocol: ADA bridging ELISA
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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Hispec Assay Diluent | BUF049A | E IY | 50 ml | Log in | |||
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Description | Hispec Assay Diluent | ||||||
Human anti Ocrelizumab | HCA400 | E | 0.1 mg |
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Description | Human anti Ocrelizumab | ||||||
Human anti Ocrelizumab | HCA401 | E | 0.1 mg |
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Description | Human anti Ocrelizumab | ||||||
LYNX Rapid HRP Antibody Conjugation Kit | LNK002P | CJ | 3 Conjugations For 400µg Antibody | Log in | |||
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Description | LYNX Rapid HRP Antibody Conjugation Kit | ||||||
Human anti Ocrelizumab | TZA044 | E | 0.1 mg |
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Description | Human anti Ocrelizumab | ||||||
Human anti Ocrelizumab | TZA045 | E | 0.1 mg |
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Description | Human anti Ocrelizumab | ||||||
Human anti Ocrelizumab:HRP | TZA045P | E | 0.1 mg |
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Description | Human anti Ocrelizumab:HRP |
- Synonyms
- Ocrevus
HCA399

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