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Ocrelizumab antibody | AbD47395ia

Human anti Ocrelizumab

Product Type
Monoclonal Antibody
Clone
AbD47395ia
Isotype
IgG1
Specificity
Ocrelizumab

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New HCA399
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Human Anti-Ocrelizumab Antibody, clone AbD47395ia is a paratope specific, inhibitory, anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody drug ocrelizumab, and its biosimilar products. It does not recognize the drug target, the B cell surface marker CD20, nor ocrelizumab in complex with CD20. This antibody can be used to measure free ocrelizumab levels in serum from patients.

Clone AbD47395ia (HCA399) is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or calibrator in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 25.6nM and is one of the three antibodies offered for ADA assays. Antibody HCA400 has an affinity of <0.001nM and HCA401 has an affinity of 0.7nM.

Ocrelizumab (trade name Ocrevus) is a humanized monoclonal antibody of the IgG1/kappa isotype developed from the monoclonal antibody drug rituximab. Ocrelizumab targets the B cell surface marker CD20. Binding of the drug to its target triggers cell death through a number of mechanisms, including apoptosis, complement activation and cell-mediated cytotoxicity. In vivo, ocrelizumab selectively and effectively depletes CD20 expressing B cells, hence acting as an immunosuppressive drug.
Ocrelizumab is used in the treatment of primary progressive multiple sclerosis and relapsing forms of multiple sclerosis in adults.

View a summary of all anti-ocrelizumab antibodies.

Product Form
Human IgG1 antibody (lambda light chain) selected from Bio-Rad’s human antibody phage display libraries. This antibody is supplied as a liquid.
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Source
HKB-11
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Ocrelizumab
Affinity
The monovalent intrinsic affinity of Human anti-Ocrelizumab Antibody, clone AbD47395ia was measured as KD = 25.6 nM by real time, label-free molecular interaction analysis on immobilized ocrelizumab.
Approx. Protein Concentrations
Antibody concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
Ocrevus is a registered trademark of Genentech/ Roche and Biogen.
Rituxan is a registered trademark of Genentech and Biogen.

This product is shipped refrigerated.
When ready to use, thaw and aliquot the sample as needed. Store aliquots at -70°C, if available, otherwise store at -20°C. It is not recommended to keep aliquots at 4°C for more than one week.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Technical Advice
Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
ELISA
This product may be used to develop and calibrate immune response assays to measure the anti-drug antibody (ADA) response in patient sera together with HCA400 and HCA401.

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Synonyms
Ocrevus
Licensed Use
For in vitro. research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.

HCA399

166854

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