Lymphotoxin Beta Receptor antibody | 5G11b
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Rat anti Mouse Lymphotoxin Beta Receptor
- Product Type
- Monoclonal Antibody
- Lymphotoxin Beta Receptor
|Rat anti Mouse Lymphotoxin beta Receptor antibody, clone 5G11b recognizes murine Tumor necrosis factor receptor superfamily member 3, also known as lymphotoxin-beta receptor, LT beta R, or Tumor necrosis factor receptor superfamily member 3. Lymphotoxin beta receptor is 385 amino acid (415 aa including 30 aa signal peptide) ~50 kDa type 1, single pass transmembrane glycoprotein and member of the tumor necrosis factor family. LT beta R is primarily expressed on stromal cells and fibroblasts and at lower levels on myeloid cell lines. Rat anti Mouse Lymphotoxin beta Receptor antibody, clone 5G11b recognizes surface expressed LT beta R.
Rat anti Mouse Lymphotoxin beta Receptor antibody, clone 5G11b is reported to be agonistic with respect to NF Kappa B activation, MIP-2 induction and IL-6 release (Hehlgans et al. 2003).
Rat anti Mouse Lymphotoxin beta Receptor antibody, clone 5G11b is routinely tested on WEH164S cells.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Recombinant extracellular domain of LT beta R.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunized Wistar rats were fused with cells of the SP2/0 - Ag14 mouse myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells in 100μl
Hehlgans T et al. (2003) Activation of the lymphotoxin-beta receptor induces NFkappaB-dependent interleukin-6 and MIP-2 secretion in mouse fibrosarcoma cells.
Eur Cytokine Netw. 14 (2): 103-7.
References for Lymphotoxin Beta Receptor antibody
Palumbo, M.O. et al. (2006) Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones.
Diabetes. 55: 2595-601.
Moore, F. et al. (2007) An alternative pathway of NF-kappaB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IkappaBalpha.
J Immunol. 178: 1301-11.
Magari, M. et al. (2011) IL-21-Dependent B Cell Death Driven by Prostaglandin E2, a Product Secreted from Follicular Dendritic Cells.
J Immunol. 187: 4210-8.
Into, T. et al. (2018) MyD88 signaling causes autoimmune sialadenitis through formation of high endothelial venules and upregulation of LTββ receptor-mediated signaling.
Sci Rep. 8 (1): 14272.
Muller, P. et al. (2001) Functional characterization of the mouse lymphotoxin-beta receptor promoter.
Eur Cytokine Netw. 12 (2): 325-30.
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