IL-17 antibody | TC11-8H4
Rat anti Mouse Interleukin-17
- Product Type
- Monoclonal Antibody
|Rat anti Mouse interleukin 17 antibody, clone TC11-8H4 recognizes mouse interleukin 17, a 32kDa disulfide-linked homodimer consisting of two 136 amino acid chains belonging to the IL-17 family (classified as IL-17A to IL-17F), and signals through the IL-17 receptor (IL-17R/CDw217).
IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. IL-17 plays a role in the development of rheumatoid arthritis, with levels of IL-17 significantly increased and may contribute to bone destruction (Chabaud et al. 2000).
Rat anti mouse interleukin-17 antibody has been successfully used for the identification of IL-17 secreting cells in a murine anti-tumor immunity model by ELISPOT analysis (Yu et al. 2013)
- Target Species
- Product Form
- Purified IgG - liquid
- Antibody purified from ascites
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
- None present
- Recombinant mouse IL-17 expressed in E. coli
- Approx. Protein Concentrations
- 0.5 mg/ml
- For research purposes only
- Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
|Application Name||Verified||Min Dilution||Max Dilution|
References for IL-17 antibody
Yu, Y. et al. (2013) Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms.
J Immunol. 190: 1873-81.
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