IL-17 antibody | TC11-8H4
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Rat anti Mouse Interleukin-17
- Product Type
- Monoclonal Antibody
- Clone
- TC11-8H4
- Isotype
- IgG1
- Specificity
- IL-17
Antibody Quality and Performance Guarantee
| Rat anti Mouse interleukin 17 antibody, clone TC11-8H4 recognizes mouse interleukin 17, a 32kDa disulfide-linked homodimer consisting of two 136 amino acid chains belonging to the IL-17 family (classified as IL-17A to IL-17F), and signals through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. IL-17 plays a role in the development of rheumatoid arthritis, with levels of IL-17 significantly increased and may contribute to bone destruction (Chabaud et al. 2000). Rat anti mouse interleukin-17 antibody has been successfully used for the identification of IL-17 secreting cells in a murine anti-tumor immunity model by ELISPOT analysis (Yu et al. 2013) |
- Target Species
- Mouse
- Product Form
- Purified IgG - liquid
- Preparation
- Antibody purified from ascites
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Recombinant mouse IL-17 expressed in E. coli
- Approx. Protein Concentrations
- 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.
Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
References for IL-17 antibody
-
Yu, Y. et al. (2013) Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms.
J Immunol. 190: 1873-81.
- Synonyms
- IL-17A
- RRID
- AB_618681
View more products with IL-17 specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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