F4/80 antibody | Cl:A3-1

Rat anti Mouse F4/80:Biotin

Product Type
Monoclonal Antibody
Clone
Cl:A3-1
Isotype
IgG2b
Specificity
F4/80

Product Code Applications Pack Size List Price Your Price Qty
MCA497B
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F 0.1 mg loader
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MCA497BB
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F 0.5 mg loader
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MCA497BT
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Rat anti Mouse F4/80 antibody, clone A3-1 recognizes the murine F4/80 antigen, a ~160 kDa cell surface glycoprotein member of the EGF-TM7 family of proteins which shares 68% overall amino acid identity with human EGF module-containing mucin-like hormone receptor 1 (EMR1).

Expression of F4/80 is heterogeneous and is modulated during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans cells, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen (Hume, et al. 1984). F4/80 antigen is also expressed on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node (Gordon, et al. 1994). The ligands and biological functions of the F4/80 antigen have not been fully determined but a role for F4/80 in the generation of efferent CD8+ve regulatory T cells is proposed (Lin, et al. 2005)

Rat anti mouse F4/80 antibody, clone Cl:A3-1 modulates cytokine levels released in response to Listeria monocytogenes (Warschkau & Kiderlen, 1999).

A Human anti-idiotypic CI:A31 antibody, clone 17867 (HCA154 ) which binds to and blocks activity of Rat anti mouse F4/80 antibody, clone Cl:A3-1 is also available for use as a control in experiments utilizing clone A3-1.
CiteAb logo - trusted, tested, published

Our F4/80 (Cl:A3-1) Antibody has been referenced in >719 publications*


*Based on June 2020 data from CiteAb's antibody search engine.

Target Species
Mouse
Product Form
Purified IgG conjugated to Biotin - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09%Sodium Azide
1%Bovine Serum Albumin
Immunogen
Thioglycollate stimulated peritoneal macrophages from C57BL/6 mice.
Approx. Protein Concentrations
Pack Size: 0.1 mg, 25 µg
IgG concentration 0.1 mg/ml
Pack Size: 0.5 mg
IgG concentration 0.5 mg/ml
Fusion Partners
Spleen cells from immunised HOB2 rats were fused with cells of the mouse NS1 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry Neat Pack Size: 0.1 mg, 25 µg
1/10 Pack Size: 0.5 mg
1/10 Pack Size: 0.1 mg, 25 µg
1/50 Pack Size: 0.5 mg
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul of the suggested working dilution to label 106 cells in 100ul.

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Source Reference

  1. Austyn, J.M. & Gordon, S. (1981) F4/80, a monoclonal antibody directed specifically against the mouse macrophage.
    Eur J Immunol. 11 (10): 805-15.

Antibody Characterization Reference

  1. Hume, D.A. et al. (1984) The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia.
    Anat Rec. 210 (3): 503-12. Anat Rec. 210 (3): 503-12.
  2. Lee, S.H. et al. (1985) Quantitative analysis of total macrophage content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80.
    J Exp Med. 161 (3): 475-89. J Exp Med. 161 (3): 475-89.

References for F4/80 antibody

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  9. View The Latest Product References
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Flow Cytometry

Immuno-electron Microscopy

Immunofluorescence

Immunohistology - Frozen

Immunohistology - Paraffin

Western Blotting

RRID
AB_322046
UniProt
Q61549
Entrez Gene
Emr1
GO Terms
GO:0005509 calcium ion binding
GO:0016021 integral to membrane
GO:0004930 G-protein coupled receptor activity
GO:0007218 neuropeptide signaling pathway
GO:0009897 external side of plasma membrane
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