CD11a antibody | I21/7
Filter by Application:F Reset
Rat anti Mouse CD11a
- Product Type
- Monoclonal Antibody
|Rat anti Mouse CD11a antibody, clone I21/7 recognizes murine CD11a, a ~170-180 kDa type I membrane glycoprotein, also known as the integrin alpha L subunit. CD11a is a member of the integrin family of adhesion molecules. CD11a is expressed on all leucocytes and associates with CD18 to form a heterodimer at the cell surface. The CD11a/CD18 heterodimer binds to intercellular adhesion molecules (ICAM); ICAM1, ICAM-2 and ICAM-3 and is involved in cell-cell adhesion processes.
Rat anti Mouse CD11a antibody, clone I21/7 is reported to block the cytolytic activity of cytotoxic T cell lines (Trowbridge and Omary 1981).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Whole BW5147 cells.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells in 100μl
|Description||Product Code||Applications||Pack Size||List Price||Your Price||Quantity|
|Rat IgG2a Negative Control||MCA1212||E F||1 ml||Log in|
|List Price||Your Price|
|Description||Rat IgG2a Negative Control|
Trowbridge, I.S. & Omary, M.B. (1981) Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1.
J Exp Med. 154 (5): 1517-24.
References for CD11a antibody
Champe, M. et al. (1995) Monoclonal antibodies that block the activity of leukocyte function-associated antigen 1 recognize three discrete epitopes in the inserted domain of CD11a.
J Biol Chem. 270 (3): 1388-94.
Barrett, T.B. et al. (1991) CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.
J Immunol. 146 (6): 1722-9.
Talento, A. et al. (1993) A single administration of LFA-1 antibody confers prolonged allograft survival.
Transplantation. 55 (2): 418-22.
Campbell, S.B. et al. (2001) CD4 ligation promotes the IL-4-independent development of IL-4-producing clones from naive CD4(+) T cells.
J Immunol. 167 (10): 5610-9.
Kleinschnitz, C. et al. (2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.
Blood. 121: 679-691
Falanga, P.B. & Butcher, E.C. (1991) Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model.
Eur J Immunol. 21 (9): 2259-63.
Chiu, W.C. et al. (2007) Effect of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in diabetic mice with sepsis.
Br J Nutr. 97 (4): 685-91.
Xuemei, H. et al. (2020) Mesenchymal stem cell–derived exosomal microRNA-34c-5p ameliorates renal pericyte activation by inhibiting core fucosylation
Res Sq 13 Oct [Epub ahead of print].
View The Latest Product References
Hu, X. et al. (2021) Bone marrow mesenchymal stem cell-derivedexosomal miR-34c-5p ameliorates RIF by inhibitingthe core fucosylation of multiple proteins.
Mol Ther. S1525-0016(21)00519-0.
Springer, T.A. et al. (1982) LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function.
Immunol Rev. 68: 171-95.
- Integrin Alpha L Chain
- Entrez Gene
- GO Terms
- GO:0001772 immunological synapse
- GO:0004872 receptor activity
- GO:0008305 integrin complex
- GO:0007159 leukocyte cell-cell adhesion
- GO:0007229 integrin-mediated signaling pathway
- GO:0009897 external side of plasma membrane
- GO:0022409 positive regulation of cell-cell adhesion
- GO:0042102 positive regulation of T cell proliferation
- GO:0050798 activated T cell proliferation
- View More GO Terms
- GO:0050850 positive regulation of calcium-mediated signaling
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"View all Anti-Mouse Products
Always be the first to know.
When we launch new products and resources to help you achieve more in the lab.Yes, sign me up