TNF Alpha antibody | cA2

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Human anti TNF Alpha (Infliximab Biosimilar)

Anti-TNF Alpha Antibody is a non-therapeutic biosimilar of the monoclonal antibody drug infliximab (Remicade) for research use. It can be used in bioanalytical PK and ADA assays and for studying biological pathways affected by the drug.

Product Type
Monoclonal Antibody
Clone
cA2
Isotype
IgG1
Product Code Applications Pack Size List Price Quantity
MCA6090
Datasheet
E
MSDS
0.2 mg loader

Human Anti-TNF alpha Antibody is a research grade biosimilar of the monoclonal antibody drug infliximab. It is a recombinant human IgG1 kappa antibody with variable regions from the therapeutic infliximab antibody clone cA2.

This antibody is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-infliximab antibodies, for example HCA214 and HCA216. It can also be used as capture and detection reagent in an anti-drug antibody (ADA) bridging ELISA, with an anti-infliximab antibody in IgG1 format as a reference standard, for example HCA213 or HCA233.

Infliximab, also known as Remicade, is a chimeric IgG1 kappa monoclonal antibody approved for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis and ulcerative colitis. This therapeutic antibody is directed against TNF alpha and acts by blocking the binding of TNF alpha to its receptors, resulting in a down-regulation of the inflammatory response associated with autoimmune diseases.

This product is NOT FOR THERAPEUTIC USE.

View a summary of supporting anti-infliximab antibody products

Product Details

Target Species
Human
Product Form
Human IgG1 (kappa) antibody - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Proclin 300
Immunogen
Human TNFα
Purity
>98% by SDS PAGE
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

Licensed Use
For in vitro research purposes only. Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals.
Regulatory
For research purposes only

Applications of TNF Alpha antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Useful Reagents Available

Description Product Code Applications Pack Size List Price Quantity
Hispec Assay Diluent BUF049A E IY 50 ml
Human anti Infliximab HCA212 E 0.1 mg loader
Human anti Infliximab HCA213 E 0.1 mg loader
Human anti Infliximab:HRP HCA213P E 0.1 mg loader
Human anti Infliximab HCA214 E 0.1 mg loader
Human anti Infliximab HCA215 E 0.1 mg loader
Human anti Infliximab HCA216 E 0.1 mg loader
Human anti Infliximab:HRP HCA216P E 0.1 mg loader
Human anti Infliximab HCA233 E 0.1 mg loader
Human anti Infliximab HCA234 E 0.1 mg loader
LYNX Rapid HRP Antibody Conjugation Kit LNK001P CJ 1 Conjugation For 400µg Antibody