TNF Alpha antibody | cA2

Human anti TNF Alpha (Infliximab Biosimilar)

Product Type
Monoclonal Antibody
Clone
cA2
Isotype
IgG1
Specificity
TNF Alpha

Product Code Applications Pack Size List Price Your Price Qty
MCA6090
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SDS Safety Datasheet SDS
E 0.2 mg loader
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Human Anti-TNF alpha Antibody is a research grade biosimilar of the monoclonal antibody drug infliximab. This product is supplied in a research grade format, i.e. in PBS buffer with preservative, it is not manufactured or formulated in the same way as the therapeutic reference product. A preservative free version is available on request.

This product is a recombinant human IgG1 kappa antibody with variable regions from the therapeutic infliximab antibody clone cA2.

This antibody is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-infliximab antibodies, for example HCA214 and HCA216. It can also be used as capture and detection reagent in an anti-drug antibody (ADA) bridging ELISA, with an anti-infliximab antibody in IgG1 format as a reference standard, for example HCA213 or HCA233.

Infliximab, also known as Remicade, is a chimeric IgG1 kappa monoclonal antibody approved for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis and ulcerative colitis. This therapeutic antibody is directed against TNF alpha and acts by blocking the binding of TNF alpha to its receptors, resulting in a down-regulation of the inflammatory response associated with autoimmune diseases.

This product is NOT FOR THERAPEUTIC USE.

View a summary of supporting anti-infliximab antibody products

Target Species
Human
Product Form
Human IgG1 (kappa) antibody - liquid
Preparation
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Proclin 300
Immunogen
Human TNFα
Purity
>98% by SDS PAGE
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Description Product Code Applications Pack Size List Price Your Price Quantity
Hispec Assay Diluent BUF049A E IY 50 ml
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Description Hispec Assay Diluent
Human anti Infliximab HCA212 E 0.1 mg loader
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loader
Description Human anti Infliximab
Human anti Infliximab HCA213 E 0.1 mg loader
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loader
Description Human anti Infliximab
Human anti Infliximab:HRP HCA213P E 0.1 mg loader
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Description Human anti Infliximab:HRP
Human anti Infliximab HCA214 E 0.1 mg loader
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loader
Description Human anti Infliximab
Human anti Infliximab HCA215 E 0.1 mg loader
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loader
Description Human anti Infliximab
Human anti Infliximab HCA216 E 0.1 mg loader
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loader
Description Human anti Infliximab
Human anti Infliximab:HRP HCA216P E 0.1 mg loader
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Description Human anti Infliximab:HRP
Human anti Infliximab HCA233 E 0.1 mg loader
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Description Human anti Infliximab
Human anti Infliximab HCA234 E 0.1 mg loader
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Description Human anti Infliximab
LYNX Rapid HRP Antibody Conjugation Kit LNK001P CJ 1 Conjugation For 400µg Antibody
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Description LYNX Rapid HRP Antibody Conjugation Kit

Licensed Use
For in vitro research purposes only. Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals.
View more products with TNF ALPHA specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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