Rabbit anti SRC antibody recognizes proto-oncogene tyrosine-protein kinase Src, also known as Src1, p60-Src and c-Src.
c-Src is a ubiquitously-expressed cytoplasmic tyrosine kinase, important for regulating diverse cellular functions (Honda et al. 2018). c-Src was the first oncogene to be identified, over-expressed and abnormally activated in cancer cells, and is the cellular counterpart of v-Src, a cancer-causing gene found in the Rous sarcoma virus (Hunter and Sefton, 1980). Src functions as a complex molecular switch, which can self-modulate its activity in response to specific signals. This is achieved by a reciprocally regulatory mechanism involving Tyr416 and Tyr527, changing the tertiary structure of Src and controlling access to its active site (Knighton et al. 1991).
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Recombinant protein of human SRC
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
non-membrane spanning protein tyrosine kinase activity
SH3/SH2 adaptor activity
signal complex assembly
epidermal growth factor receptor signaling pathway
intracellular protein kinase cascade
Ras protein signal transduction
fibroblast growth factor receptor signaling pathway
cellular membrane organization
T cell costimulation
positive regulation of integrin activation
cell junction assembly
SH2 domain binding
regulation of vascular permeability
interspecies interaction between organisms
regulation of bone resorption
nerve growth factor receptor signaling pathway
response to interleukin-1
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of SRC antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available