Spastin antibody | RM346
Rabbit anti Spastin
- Product Type
- Monoclonal Antibody
- Clone
- RM346
- Isotype
- IgG
- Specificity
- Spastin
Antibody Quality and Performance Guarantee
| Rabbit anti spastin antibody recognizes spastin, also known as spastic paraplegia 4 protein and SPAST. Spastin is an ATPase which uses energy from ATP hydrolysis to promote microtubule severing. The two spastin isoforms are ubiquitously-expressed but have different subcellular locations (primarily the cytoplasm and endoplasmic reticulum). They appear to work together to promote fission of fubulues from the early sorting endosome (Allison et al. 2019). In addition to severing microtubules, spastin promotes regrowth of microtubules in an ATP-independent way, revealing its function as a dual-microtubule regulator (Kuo et al. 2019). Spastin is involved with remodeling of membrane structures, relevant for neurite branching, axonal growth, midbody abscission, and endosome tubulation (Papadopoulos et al. 2015). Mutations in spastin are a common cause of Hereditary Spastic Paraplegia (HSP), a group of diseases characterized by spasticity and gait disorders (Arribat et al. 2020). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the N-terminus of human spastin
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/500 | 1/1000 |
| Western Blotting | |
1/500 | 1/1000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- Q9UBP0
- Entrez Gene
- SPAST
- GO Terms
- GO:0001578 microtubule bundle formation
- GO:0016021 integral to membrane
- GO:0005783 endoplasmic reticulum
- GO:0005524 ATP binding
- GO:0005634 nucleus
- GO:0005768 endosome
- GO:0005815 microtubule organizing center
- GO:0005819 spindle
- GO:0005874 microtubule
- View More GO Terms
- GO:0006888 ER to Golgi vesicle-mediated transport
- GO:0007049 cell cycle
- GO:0007109 cytokinesis, completion of separation
- GO:0007399 nervous system development
- GO:0008017 microtubule binding
- GO:0008219 cell death
- GO:0051013 microtubule severing
- GO:0008568 microtubule-severing ATPase activity
- GO:0030154 cell differentiation
- GO:0034214 protein hexamerization
- GO:0051260 protein homooligomerization
- GO:0043014 alpha-tubulin binding
- GO:0048471 perinuclear region of cytoplasm
- GO:0048487 beta-tubulin binding
MCA6350
157613
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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