RIP3 antibody | OTI1D9

Mouse anti RIP3

Product Type
PrecisionAb Monoclonal
Clone
OTI1D9
Isotype
IgG2b
Format
Purified
Specificity
RIP3

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VMA00393
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Mouse anti Human RIP3 antibody, clone OTI1D9 recognizes RIP3, also known as RIP-like protein kinase 3, receptor interacting protein 3 and receptor-interacting serine/threonine-protein kinase 3.

The product of the RIPK3 gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The RIP3 protein is predominantly localized to the cytoplasm, and can undergo nucleo-cytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor (provided by RefSeq, Jul 2008).

Mouse anti Human RIP3 antibody detects a band of 57 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti RIP3 detects a band of approximately 57 kDa in Jurkat cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Recombinant protein fragment corresponding to aa 233-518 of human RIP3 (NP_006862) produced in E.coli
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q9Y572
Entrez Gene
RIPK3
GO Terms
GO:0005515 protein binding
GO:0003713 transcription coactivator activity
GO:0006915 apoptosis
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0008624 induction of apoptosis by extracellular signals
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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