PSME1 antibody | AB02/4C4

Mouse anti PSME1

Product Type
PrecisionAb Monoclonal
Clone
AB02/4C4
Isotype
IgG1
Format
Purified
Specificity
PSME1

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VMA00917
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Mouse anti PSME1 antibody recognizes proteasome activator complex subunit 1, also known as REG-alpha, IGUP I-5111, and PA28a.

PSME1 encodes a subunit of the proteinase system, required for efficient processing of antigens and for assembly of the immunoproteasome (Vigneron and Van den Eynde 2014). Antigen presenting cells and many other cell types express PSME1 under the control of interferon gamma. PSME1 is involved with immune defense against cancer, by generating tumor antigens presented by MHC class I molecules. High expression of PSME1 is associated with poor metastasis-free survival in patients with soft tissue leiomyosarcoma, and has been suggested as a prognostic biomarker for this cancer type (Lou et al. 2016), and also esophageal squamous cell carcinoma (Zhang et al. 2011) and prostate cancer (Sanchez-Martin et al. 2013).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti PSME1 detects a band of approximately 31 kDa in MCF-7 cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-249 of human PSME1
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q06323
Entrez Gene
PSME1
GO Terms
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000084 S phase of mitotic cell cycle
GO:0000216 M/G1 transition of mitotic cell cycle
GO:0006915 apoptosis
GO:0005737 cytoplasm
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008537 proteasome activator complex
GO:0016032 viral reproduction
GO:0016071 mRNA metabolic process
GO:0042981 regulation of apoptosis
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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