PI-3 Kinase C2 Subunit Alpha antibody | OTI1B8

Mouse anti PI-3 Kinase C2 Subunit Alpha

Product Type
PrecisionAb Monoclonal
Clone
OTI1B8
Isotype
IgG2b
Format
Purified
Specificity
PI-3 Kinase C2 Subunit Alpha

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VMA00263
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WB 100 µl loader
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Mouse anti Human PI-3 kinase C2 subunit alpha antibody, clone OTI1B8 recognizes the phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, also known as C2-containing phosphatidylinositol kinase, PI3K-C2-alpha, PI3K-C2alpha, phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha, phosphoinositide 3-kinase-C2-alpha, phosphoinositide-3-kinase, class 2, alpha polypeptide and ptdIns-3-kinase C2 subunit alpha.

The protein encoded by PIK3C2A gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. (provided by RefSeq, Jul 2008).

Mouse anti Human PI-3 kinase C2 subunit alpha antibody, clone OTI1B8 detects a band of 191 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti PI-3 Kinase C2 subunit alpha detects a band of approximately 191 kDa in C6 cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Recombinant protein corresponding to amino acids 230-560 of human PI-3 C2 subunit alpha (NP_002636) produced in E. coli
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
O00443
Entrez Gene
PIK3C2A
GO Terms
GO:0005886 plasma membrane
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007154 cell communication
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0035005 phosphatidylinositol-4-phosphate 3-kinase activity
GO:0048015 phosphatidylinositol-mediated signaling
GO:0030136 clathrin-coated vesicle
GO:0035091 phosphatidylinositol binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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