PI-3 Kinase C2 Subunit Alpha antibody | OTI1B8

Mouse anti Human PI-3 kinase C2 subunit alpha antibody recognizes the phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, also known as C2-containing phosphatidylinositol kinase, PI3K-C2-alpha, PI3K-C2alpha, phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha, phosphoinositide 3-kinase-C2-alpha, phosphoinositide-3-kinase, class 2, alpha polypeptide and ptdIns-3-kinase C2 subunit alpha.

The protein encoded by PIK3C2A gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. (provided by RefSeq, Jul 2008).

Mouse anti Human PI-3 kinase C2 subunit alpha antibody detects a band of 191 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000