MyD88 antibody | RM306

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Rabbit anti MyD88

Product Type
Monoclonal Antibody
Clone
RM306
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6343
Datasheet
P WB
SDS
0.1 ml loader

Rabbit anti MyD88 antibody recognizes myeloid differentiation primary response protein MyD88.

MyD88 is a central adaptor protein for inflammatory signaling downstream of Toll-like receptors and interleukin-1 receptors at the plasma membrane or in endosomes. Signaling through MyD88 can lead to inflammatory or anti-inflammatory cytokine production and type I interferon production (Deguine and Barton 2014). Mutations in MyD88 lead to constitutive activation of NF-kappaB and associated pathways. This activation underlies the B-cell proliferation and survival within B-cell lymphomas and accounts for the role of MyD88 as an oncogenic driver (de Groen et al. 2019). Deficiency in MyD88 has been shown to result in increased susceptibility to injury and infection in the cornea and other tissues (Reins et al. 2017).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the N-terminus of human MyD88

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
Q99836
Entrez Gene
MYD88
GO Terms
GO:0005886 plasma membrane
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0005829 cytosol
GO:0004888 transmembrane receptor activity
GO:0005123 death receptor binding
GO:0006916 anti-apoptosis
GO:0006954 inflammatory response
GO:0008063 Toll signaling pathway
GO:0010008 endosome membrane
GO:0031224 intrinsic to membrane
GO:0032740 positive regulation of interleukin-17 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032755 positive regulation of interleukin-6 production
GO:0034130 toll-like receptor 1 signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045087 innate immune response
GO:0048011 nerve growth factor receptor signaling pathway
GO:0050727 regulation of inflammatory response
GO:0070555 response to interleukin-1
Regulatory
For research purposes only

Applications of MyD88 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/100 1/250
Western Blotting 1/100 1/200
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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