Rabbit anti MMP-12 antibody
recognizes macrophage metalloelastase, also known as MME and HME.
Matrixmetalloproteinases (MMPs) are endopeptidases involved with angiogenesis, tumor invasion and metastasis (Klupp et al. 2016
). MMP12 is a protease secreted from macrophages, and is a potent elastase (Wolf et al. 2019
). It is involved with macrophage migration, but also appears to play a role in regulating the resolution of inflammation (Collison 2018
). MMP12 is involved with oncogenic processes, appearing to be a critical regulator of malignancies. Knockdown of MMP12 in lung adenovirus cells inhibits tumor growth and invasion (Lv et al. 2015
). MMP12 also appears to play a role in age-dependent stiffening of arteries (Brankovic et al. 2019
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the C-terminus of human MMP-12
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
calcium ion binding
proteinaceous extracellular matrix
zinc ion binding
wound healing, spreading of epidermal cells
positive regulation of epithelial cell proliferation involved in wound healing
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of MMP-12 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
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