MMP-12 antibody | RM381

Rabbit anti MMP-12

Product Type
Monoclonal Antibody
Clone
RM381
Isotype
IgG
Specificity
MMP-12

Product Code Applications Pack Size List Price Your Price Qty
MCA6356
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SDS Safety Datasheet SDS
P WB 0.1 ml loader
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Rabbit anti MMP-12 antibody recognizes macrophage metalloelastase, also known as MME and HME.

Matrixmetalloproteinases (MMPs) are endopeptidases involved with angiogenesis, tumor invasion and metastasis (Klupp et al. 2016). MMP12 is a protease secreted from macrophages, and is a potent elastase (Wolf et al. 2019). It is involved with macrophage migration, but also appears to play a role in regulating the resolution of inflammation (Collison 2018). MMP12 is involved with oncogenic processes, appearing to be a critical regulator of malignancies. Knockdown of MMP12 in lung adenovirus cells inhibits tumor growth and invasion (Lv et al. 2015). MMP12 also appears to play a role in age-dependent stiffening of arteries (Brankovic et al. 2019).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the C-terminus of human MMP-12
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/1000 1/2500
Western Blotting 1/200 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P39900
Entrez Gene
MMP12
GO Terms
GO:0005509 calcium ion binding
GO:0004222 metalloendopeptidase activity
GO:0005578 proteinaceous extracellular matrix
GO:0006508 proteolysis
GO:0008270 zinc ion binding
GO:0035313 wound healing, spreading of epidermal cells
GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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