MMP-12 antibody | RM381
Rabbit anti MMP-12
- Product Type
- Monoclonal Antibody
- Clone
- RM381
- Isotype
- IgG
- Specificity
- MMP-12
Antibody Quality and Performance Guarantee
| Rabbit anti MMP-12 antibody recognizes macrophage metalloelastase, also known as MME and HME. Matrixmetalloproteinases (MMPs) are endopeptidases involved with angiogenesis, tumor invasion and metastasis (Klupp et al. 2016). MMP12 is a protease secreted from macrophages, and is a potent elastase (Wolf et al. 2019). It is involved with macrophage migration, but also appears to play a role in regulating the resolution of inflammation (Collison 2018). MMP12 is involved with oncogenic processes, appearing to be a critical regulator of malignancies. Knockdown of MMP12 in lung adenovirus cells inhibits tumor growth and invasion (Lv et al. 2015). MMP12 also appears to play a role in age-dependent stiffening of arteries (Brankovic et al. 2019). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the C-terminus of human MMP-12
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/1000 | 1/2500 |
| Western Blotting | |
1/200 | 1/1000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P39900
- Entrez Gene
- MMP12
- GO Terms
- GO:0005509 calcium ion binding
- GO:0004222 metalloendopeptidase activity
- GO:0005578 proteinaceous extracellular matrix
- GO:0006508 proteolysis
- GO:0008270 zinc ion binding
- GO:0035313 wound healing, spreading of epidermal cells
- GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
MCA6356
157619
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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