MALT1 antibody | 50

Mouse anti MALT1

Product Type
PrecisionAb Monoclonal
Clone
50
Isotype
IgG1
Format
Purified
Specificity
MALT1

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VMA00038
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SDS Safety Datasheet SDS
IP P * WB 100 µl loader
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Mouse anti Human MALT1 antibody recognizes human mucosal-associated lymphoid tissue lymphoma translocation 1 (MALT1), also known as MALT lymphoma-associated translocation and paracaspase. MALT1 is an 824 amino acid protein belonging to the peptidase C14B family containing a single death domain and two Ig-like C2-type domains. In normal lymphocytes, MALT1 plays an important role in antigen receptor-mediated lymphocyte activation. In T-cells MALT1 is recruited by activated CARMA1, along with Bcl-10, to form a CARMA1-Bcl10-MALT1 (CBM) complex which is involved in the activation of NF-kappaB (Yang et al. 2013).

MALT1 was initially identified as a recurrent translocation t(11;18)(q21:q21) in mucosal-associated lymphomas (Horsman et al. 1992), which creates a functional fusion oncoprotein consisting of MALT1 and apoptosis inhibitor API2 (Dierlamm et al. 1999). Overexpression of MALT1, or expression of the API2-MALT1 fusion protein, leads to the uncontrolled activation of NF-kappaB which is stimulus-independent (Zhou et al. 2005). Mouse anti Human MALT1 recognizes both MALT1 and the MALT1-API2 fusion protein (Murga Penas et al. 2007). The MALT1-API2 oncoprotein plays a role in non-canonical activation of NF-κb through NIK cleavage (Rosebeck et al.2011).

Mouse anti Human MALT1 antibody recognizes human MALT1 as a single band of ~92 kDa in multiple human cell line lysates by western blotting under reducing conditions.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti MALT1 antibody detects a band of approximately 92 kDa in HEK293 cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Recombinant protein corresponding to amino acids 701-808 located within the C-terminus of human MALT1
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20oC, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1
Immunoprecipitation
Western Blotting 1/1000
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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References for MALT1 antibody

  1. Ye, H. et al. (2005) MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression.
    J Pathol. 205 (3): 293-301.
  2. Coornaert, B. et al. (2008) T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.
    Nat Immunol. 9 (3): 263-71.
  3. Rebeaud, F. et al. (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation.
    Nat Immunol. 9 (3): 272-81.

UniProt
Q9UDY8
Entrez Gene
MALT1
GO Terms
GO:0004197 cysteine-type endopeptidase activity
GO:0002726 positive regulation of T cell cytokine production
GO:0005829 cytosol
GO:0004842 ubiquitin-protein ligase activity
GO:0004871 signal transducer activity
GO:0005634 nucleus
GO:0006508 proteolysis
GO:0006916 anti-apoptosis
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0032449 CBM complex
GO:0032743 positive regulation of interleukin-2 production
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043621 protein self-association
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0051168 nuclear export
GO:0051259 protein oligomerization
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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