LIN28B antibody | CD03/4D4
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WB ResetMouse anti LIN28B
- Product Type
- PrecisionAb Monoclonal
- Clone
- CD03/4D4
- Isotype
- IgG1
- Format
- Purified
- Specificity
- LIN28B
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| Mouse anti LIN28B antibody recognizes protein lin-28 homolog B, also known as CSDD2. LIN28B is a cytoplasmic RNA-binding protein (RBP) involved with orchestrating fetal hematopoiesis, able to specify the fate of hematopoietic stem and progenitor cells (HSPCs) (Wang et al. 2019). It is therefore highly expressed in embryonic tissues. LIN28B is completely silenced during differentiation and in healthy adult tissues, but is reactivated in numerous cancers - it is an oncofetal protein. Its expression has been associated with advanced disease and poor prognosis (Kugel et al. 2016). During pregnancy, decreased expression of LIN28B has been suggested to play a role in preeclampsia via reduction in trophoblast invasion and syncytialization and by promoting inflammation, hindering differentiation and migration of trophoblasts (Canfield et al. 2019). |
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- Target Species
- Human
- Western Blotting
- Mouse anti LIN28B antibody detects a band of approximately 24 and 33 kDa in HepG2 cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-250 of human LIN28B
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- Q6ZN17
- Entrez Gene
- LIN28B
- GO Terms
- GO:0005515 protein binding
- GO:0003677 DNA binding
- GO:0003723 RNA binding
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0006355 regulation of transcription, DNA-dependent
- GO:0008270 zinc ion binding
- GO:0010587 miRNA catabolic process
- GO:0031054 pre-microRNA processing
- View More GO Terms
- GO:0031123 RNA 3'-end processing
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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