Rabbit anti Ki67 antibody
recognizes proliferation marker protein Ki-67, also known as MKI67.
Ki67 is a nuclear marker which exists in proliferating cells, with levels decaying steadily in quiescent cells. It is a cell cycle protein present during G1, S, and G2 phases, and its transcription is under the control of E2F activation. Ki67 has been shown to participate in ribosomal biogenesis, heterochromatin organization, and mitotic chromosome separation (Miller et al. 2018
). Ki67 is a widely-used indicator of proliferation in oncology across numerous cancer types. In breast cancer, Ki67 may be an indicator of responsiveness or resistance to chemotherapy or endocrine therapy (Niazi et al. 2018
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the internal region of human Ki67
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
protein C-terminus binding
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Ki67 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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