KAT7 antibody | EF01/2H10

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Mouse anti KAT7

Product Type
PrecisionAb Monoclonal
Clone
EF01/2H10
Isotype
IgG1
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00966
Datasheet
WB
SDS
100 µl loader

Mouse anti KAT7 antibody recognizes histone acetyltransferase KAT7, also known as HBO1, MYST2. KAT7 is a member of the MYST-type histone acetyltransferases and is required for acetylation of histones H3 and H4 (Izumikawa et al. 2019). This acetylation function allows KAT7 to play a role in regulation of transcription, DNA replication, and cell survival. KAT7 has been found to have cell-specific functions and can perform cell-specific gene expression. These cell-specific roles may be explained by differences in KAT7 complexes between cells (Yan et al. 2018). KAT7 is highly expressed in several human cancers, including primary ovarian cancer, breast adenocarcinoma and testicular germ cell tumors. However, KAT7 has also been found to have anti-cancer effects in other cell types. For example, KAT7 expression is suppressed in acute myeloid leukemia (Quintela et al. 2019).

Product Details

Target Species
Human
Western Blotting
Mouse anti KAT7 detects a band of approximately 71 kDa in MCF-7 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-331 of human KAT7
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
O95251
Entrez Gene
MYST2
GO Terms
GO:0006260 DNA replication
GO:0000123 histone acetyltransferase complex
GO:0005515 protein binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004402 histone acetyltransferase activity
GO:0006355 regulation of transcription, DNA-dependent
GO:0008270 zinc ion binding
GO:0043966 histone H3 acetylation
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043983 histone H4-K12 acetylation
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of KAT7 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/2000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml

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