KAT7 antibody | EF01/2H10
Mouse anti KAT7
- Product Type
- PrecisionAb Monoclonal
- Clone
- EF01/2H10
- Isotype
- IgG1
- Format
- Purified
- Specificity
- KAT7
Antibody Quality and Performance Guarantee
| Mouse anti KAT7 antibody recognizes histone acetyltransferase KAT7, also known as HBO1, MYST2. KAT7 is a member of the MYST-type histone acetyltransferases and is required for acetylation of histones H3 and H4 (Izumikawa et al. 2019). This acetylation function allows KAT7 to play a role in regulation of transcription, DNA replication, and cell survival. KAT7 has been found to have cell-specific functions and can perform cell-specific gene expression. These cell-specific roles may be explained by differences in KAT7 complexes between cells (Yan et al. 2018). KAT7 is highly expressed in several human cancers, including primary ovarian cancer, breast adenocarcinoma and testicular germ cell tumors. However, KAT7 has also been found to have anti-cancer effects in other cell types. For example, KAT7 expression is suppressed in acute myeloid leukemia (Quintela et al. 2019). |
|
- Target Species
- Human
- Western Blotting
- Mouse anti KAT7 detects a band of approximately 71 kDa in MCF-7 cell lysates
- Species Cross-Reactivity
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Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-331 of human KAT7
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/2000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- O95251
- Entrez Gene
- MYST2
- GO Terms
- GO:0006260 DNA replication
- GO:0000123 histone acetyltransferase complex
- GO:0005515 protein binding
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0004402 histone acetyltransferase activity
- GO:0006355 regulation of transcription, DNA-dependent
- GO:0008270 zinc ion binding
- GO:0043966 histone H3 acetylation
- GO:0043981 histone H4-K5 acetylation
- View More GO Terms
- GO:0043982 histone H4-K8 acetylation
- GO:0043983 histone H4-K12 acetylation
VMA00966
100005827
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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