IL-7 antibody | BVD10-40F6

Rat anti Human Interleukin-7

Product Type
Monoclonal Antibody
Clone
BVD10-40F6
Isotype
IgG1
Specificity
IL-7

Product Code Applications Pack Size List Price Your Price Qty
1012201
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 0.5 mg
List Price Your Price
Search for Batch Specific Datasheets

Rat anti Human Interleukin-7 antibody, clone BVD10-40F6 recognizes human interleukin 7 (IL-7), also known as Lymphopoietin 1 or pre-B cell factor. IL-7 is a 177 amino acid haematopoietic growth factor stimulating primarily early B and T lymphocytes. IL- 7 is required for development of T-cells in the thymus (Plum et al. 1996) and absence of the IL-7 receptor α chain (CD127) leads to a severe combined immunodeficiency condition through the lack of T-cell production (Roifman et al. 2000). IL-7 is also important post-thymically for homeostasis of naive T-cell populations and generation and survival of CD4+ memory T-cells (Kondrack et al. 2003).

IL-7 deficiency or deficient function is also noted in immunodeficiency diseases including rheumatoid arthritis (Leonard 2005), chronic colitis (Totsuka et al. 2007). Multiple sclerosis through CD127 (Svejgaard 2008) and diabetes (Li et al. 2011).

Rat anti Human Interleukin-7 antibody, clone BVD10-40F6 has been used successfully in the development of a sensitive ELISA assay as a capture reagent for human IL-7.

Target Species
Human
Product Form
Purified IgG - liquid
Buffer Solution
Borate buffered saline
Preservative Stabilisers
None present
Approx. Protein Concentrations
0.5 mg/ml
Regulatory
For research purposes only
Guarantee
Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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RRID
AB_2125814
UniProt
P13232
Entrez Gene
IL7
GO Terms
GO:0005125 cytokine activity
GO:0005139 interleukin-7 receptor binding
GO:0005615 extracellular space
GO:0006959 humoral immune response
GO:0007267 cell-cell signaling
GO:0009887 organ morphogenesis
GO:0008083 growth factor activity
GO:0030890 positive regulation of B cell proliferation
GO:0045453 bone resorption
GO:0045582 positive regulation of T cell differentiation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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