hnRNP C antibody | AB05/4F12

Mouse anti hnRNP C

Product Type
PrecisionAb Monoclonal
Clone
AB05/4F12
Isotype
IgG1
Format
Purified
Specificity
hnRNP C

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VMA00820
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IP WB 100 µl loader
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Mouse anti hnRNP C antibody recognizes heterogeneous nuclear ribonucleoproteins C1/C2, also known as HNRPC.

hnRNP C is a ubiquitously expressed nuclear RNA-binding protein that can associate with all nascent mRNA transcripts (Zarnack et al. 2013). This protein is involved with stages of RNA maturation including pre-mRNA splicing, mRNA stability, and translational modulation (Nasrin et al. 2014), and one of its main functions appears to be protection of the human transcriptome from aberrant Alu exonization (Zarnack et al. 2013). In addition, hnRNP C plays roles in cell proliferation and differentiation. During the G2/M phase of the cell cycle, hnRNP C translocates from the nucleus to the cytoplasm where it is able to affect translation and regulate mitosis (Yang et al. 2013).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti hnRNP C antibody detects a band of approximately 40 kDa in HEK293 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-306 of human hnRNP C
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P07910
Entrez Gene
HNRNPC
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