Rabbit anti Human GFAP antibody, clone RM246
recognizes glial fibrillary acidic protein (GFAP). GFAP plays a role in several cellular functions within the central nervous system (CNS), including cell structure and stability, communication, motility and mitosis, and is rapidly synthesized during astrogliosis following trauma/injury (Eng and Ghirnikar 1994
). GFAP is an intermediate filament protein that is primarily expressed in astrocytes, and is upregulated following injury to the central nervous system (CNS) (Brenner et al. 2014
), inhibiting the inflammatory response and limiting damage within a controllable region (Zhang et al. 2017
). Dominant acting mutations in GFAP leading to elevated GFAP levels in astrocytes is characteristic of Alexander disease, a fatal neurological illness (Messing et al. 2019
). GFAP is also a potential marker for tumors with cartilaginous differentiation (Santos et al. 2009
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the N-terminus of Human GFAP
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
- 12 months from date of despatch
- Entrez Gene
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of GFAP antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
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