GFAP antibody | RM246

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Rabbit anti GFAP

Product Type
Monoclonal Antibody
Clone
RM246
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6305
Datasheet
P WB
SDS
0.1 ml loader

Rabbit anti Human GFAP antibody recognizes glial fibrillary acidic protein (GFAP). GFAP plays a role in several cellular functions within the central nervous system (CNS), including cell structure and stability, communication, motility and mitosis, and is rapidly synthesized during astrogliosis following trauma/injury (Eng and Ghirnikar 1994). GFAP is an intermediate filament protein that is primarily expressed in astrocytes, and is upregulated following injury to the central nervous system (CNS) (Brenner et al. 2014), inhibiting the inflammatory response and limiting damage within a controllable region (Zhang et al. 2017). Dominant acting mutations in GFAP leading to elevated GFAP levels in astrocytes is characteristic of Alexander disease, a fatal neurological illness (Messing et al. 2019). GFAP is also a potential marker for tumors with cartilaginous differentiation (Santos et al. 2009).

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the N-terminus of Human GFAP

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Guarantee
12 months from date of despatch

More Information

UniProt
P14136
Entrez Gene
GFAP
Regulatory
For research purposes only

Applications of GFAP antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/200 1/500
Western Blotting 1/1000 1/3000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

Fluorescent Spectraviewer

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  • Select combined or multi-laser view to visualize the spectra