FKBP4 antibody | 4B02/1A9

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Mouse anti FKBP4

Product Type
PrecisionAb Monoclonal
Clone
4B02/1A9
Isotype
IgG2b
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00851
Datasheet
WB
SDS
100 µl loader

Mouse anti FKBP4 antibody recognizes peptidyl-prolyl cis-trans isomerase FKBP4, also known as p59 and rotamase.

FKBP4 is a member of the immunophilin class of co-chaperones, and also acts as a PPIase. Specifically, FKBP4 is a co-chapherone of Hsp90, required for RNA interference (RNAi) (Pare et al. 2013). FKBP4 is involved with embryonic implantation and decidualization, and expression is altered in the eutopic endometrium of women with endometriosis (Joshi et al. 2017). Downregulation of FKBP4 may be a significant contributor to infertility in patients who have endometriosis (Yang et al. 2012). The FKBP4 protein is also a component of the androgen receptor complex, required for the nuclear translocation of androgen receptor after ligand binding. It has been suggested as a therapeutic target in castration-resistant prostate cancer (Federer-Gsponer et al. 2018)

Product Details

Target Species
Human
Western Blotting
Mouse anti FKBP4 antibody detects a band of approximately 57 kDa in HEK293 cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-459 of human FKBP4
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
Q02790
Entrez Gene
FKBP4
GO Terms
GO:0006457 protein folding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0030674 protein binding, bridging
GO:0005829 cytosol
GO:0005528 FK506 binding
GO:0005634 nucleus
GO:0005874 microtubule
GO:0010977 negative regulation of neuron projection development
GO:0031072 heat shock protein binding
GO:0031111 negative regulation of microtubule polymerization or depolymerization
GO:0044295 axonal growth cone
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of FKBP4 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml

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