FKBP4 antibody | 4B02/1A9
Mouse anti FKBP4 antibody recognizes peptidyl-prolyl cis-trans isomerase FKBP4, also known as p59 and rotamase.
FKBP4 is a member of the immunophilin class of co-chaperones, and also acts as a PPIase. Specifically, FKBP4 is a co-chapherone of Hsp90, required for RNA interference (RNAi) (Pare et al. 2013). FKBP4 is involved with embryonic implantation and decidualization, and expression is altered in the eutopic endometrium of women with endometriosis (Joshi et al. 2017). Downregulation of FKBP4 may be a significant contributor to infertility in patients who have endometriosis (Yang et al. 2012). The FKBP4 protein is also a component of the androgen receptor complex, required for the nuclear translocation of androgen receptor after ligand binding. It has been suggested as a therapeutic target in castration-resistant prostate cancer (Federer-Gsponer et al. 2018)
FKBP4 is a member of the immunophilin class of co-chaperones, and also acts as a PPIase. Specifically, FKBP4 is a co-chapherone of Hsp90, required for RNA interference (RNAi) (Pare et al. 2013). FKBP4 is involved with embryonic implantation and decidualization, and expression is altered in the eutopic endometrium of women with endometriosis (Joshi et al. 2017). Downregulation of FKBP4 may be a significant contributor to infertility in patients who have endometriosis (Yang et al. 2012). The FKBP4 protein is also a component of the androgen receptor complex, required for the nuclear translocation of androgen receptor after ligand binding. It has been suggested as a therapeutic target in castration-resistant prostate cancer (Federer-Gsponer et al. 2018)
Product Details
- Target Species
- Human
- Western Blotting
- Mouse anti FKBP4 antibody detects a band of approximately 57 kDa in HEK293 cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-459 of human FKBP4
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q02790
- Entrez Gene
- FKBP4
- GO Terms
- GO:0006457 protein folding
- GO:0003755 peptidyl-prolyl cis-trans isomerase activity
- GO:0030674 protein binding, bridging
- GO:0005829 cytosol
- GO:0005528 FK506 binding
- GO:0005634 nucleus
- GO:0005874 microtubule
- GO:0010977 negative regulation of neuron projection development
- GO:0031072 heat shock protein binding
- GO:0031111 negative regulation of microtubule polymerization or depolymerization
- GO:0044295 axonal growth cone
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of FKBP4 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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