Rabbit anti Human desmin antibody
recognizes desmin (DES). Desmin is the intermediate filament protein in striated muscle, and maintains the structural and functional integrity of muscle cells (Singh and Robbins 2018
). Mutations in the desmin gene, or post-translational modifications, cause skeletal and cardiac myopathies known as desmin related myopathies (DRMs) and include mitochondrial defects, cardiomyocyte death, muscle degeneration and other conditions (Capetanaki et al. 2015
). Desmin is frequently down-regulated in cardiac pathology, and is believed to play a role in progression of heart failure (Deliu et al. 2017
). Desmin expression is significantly expressed in colorectal cancer (CRC) and adenomas compared with normal colonic tissue and disrupts the function of the tumor suppressor p53, a mechanism which could explain the poor prognosis associated with high desmin expression (Li et al. 2017
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to Human desmin
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
- 12 months from date of despatch
- Entrez Gene
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Desmin antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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