Desmin antibody | RM234

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Rabbit anti Desmin

Product Type
Monoclonal Antibody
Clone
RM234
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6300
Datasheet
P WB
SDS
0.1 ml loader

Rabbit anti Human desmin antibody recognizes desmin (DES). Desmin is the intermediate filament protein in striated muscle, and maintains the structural and functional integrity of muscle cells (Singh and Robbins 2018). Mutations in the desmin gene, or post-translational modifications, cause skeletal and cardiac myopathies known as desmin related myopathies (DRMs) and include mitochondrial defects, cardiomyocyte death, muscle degeneration and other conditions (Capetanaki et al. 2015). Desmin is frequently down-regulated in cardiac pathology, and is believed to play a role in progression of heart failure (Deliu et al. 2017). Desmin expression is significantly expressed in colorectal cancer (CRC) and adenomas compared with normal colonic tissue and disrupts the function of the tumor suppressor p53, a mechanism which could explain the poor prognosis associated with high desmin expression (Li et al. 2017).

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Bovine Expected from Sequence
Rat Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to Human desmin

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Guarantee
12 months from date of despatch

More Information

UniProt
P17661
Entrez Gene
DES
Regulatory
For research purposes only

Applications of Desmin antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/1000 1/4000
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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