CD49d antibody | RM268
Rabbit anti Human CD49d antibody recognizes integrin alpha-4 (ITGA4). Integrins are transmembrane alpha-beta heterodimers, expressed on nearly every cell type, which mediate attachment to the extracellular matrix. By regulating membrane traffic, integrins are important regulators of cell proliferation and migration. CD49d is a subunit of integrin alpha, which forms a heterodimer with integrin beta1 (VLA4), the specific marker of hematopoietic cells (Cho et al. 2018). Overexpression of CD49d has been reported in several cancers (Darzi et al. 2017). Accordingly, CD49d has been suggested as a prognostic marker in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (Gooden et al. 2018) and glioblastoma (Cho et al. 2018).
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the C-terminus of Human CD49d
Storage Information
- Storage
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P13612
- Entrez Gene
- ITGA4
- GO Terms
- GO:0007596 blood coagulation
- GO:0004872 receptor activity
- GO:0008305 integrin complex
- GO:0007159 leukocyte cell-cell adhesion
- GO:0007229 integrin-mediated signaling pathway
- GO:0042802 identical protein binding
- GO:0030183 B cell differentiation
- GO:0050776 regulation of immune response
- GO:0050900 leukocyte migration
- Regulatory
- For research purposes only
Applications of CD49d antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin | 1/1000 | 1/5000 | |
| Western Blotting | 1/1000 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
|
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| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
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| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
|
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| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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