Rabbit anti Human CD49d antibody recognizes integrin alpha-4 (ITGA4). Integrins are transmembrane alpha-beta heterodimers, expressed on nearly every cell type, which mediate attachment to the extracellular matrix. By regulating membrane traffic, integrins are important regulators of cell proliferation and migration. CD49d is a subunit of integrin alpha, which forms a heterodimer with integrin beta1 (VLA4), the specific marker of hematopoietic cells (Cho et al. 2018). Overexpression of CD49d has been reported in several cancers (Darzi et al. 2017). Accordingly, CD49d has been suggested as a prognostic marker in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (Gooden et al. 2018) and glioblastoma (Cho et al. 2018).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the C-terminus of Human CD49d
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
- 12 months from date of despatch
- Entrez Gene
- GO Terms
leukocyte cell-cell adhesion
integrin-mediated signaling pathway
identical protein binding
B cell differentiation
regulation of immune response
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD49d antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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