CD49d antibody | RM268

Rabbit anti CD49d

Product Type
Monoclonal Antibody
Clone
RM268
Isotype
IgG
Specificity
CD49d

Product Code Applications Pack Size List Price Your Price Qty
MCA6314
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
P WB 0.1 ml loader
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Rabbit anti Human CD49d antibody recognizes integrin alpha-4 (ITGA4). Integrins are transmembrane alpha-beta heterodimers, expressed on nearly every cell type, which mediate attachment to the extracellular matrix. By regulating membrane traffic, integrins are important regulators of cell proliferation and migration. CD49d is a subunit of integrin alpha, which forms a heterodimer with integrin beta1 (VLA4), the specific marker of hematopoietic cells (Cho et al. 2018). Overexpression of CD49d has been reported in several cancers (Darzi et al. 2017). Accordingly, CD49d has been suggested as a prognostic marker in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (Gooden et al. 2018) and glioblastoma (Cho et al. 2018).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the C-terminus of Human CD49d
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/1000 1/5000
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P13612
Entrez Gene
ITGA4
GO Terms
GO:0007596 blood coagulation
GO:0004872 receptor activity
GO:0008305 integrin complex
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0042802 identical protein binding
GO:0030183 B cell differentiation
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
View more products with CD49 specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Human Products