Rabbit anti CD276 antibody
recognizes CD276 antigen, also known as B7-H3.
CD276 is a type I transmembrane protein which acts as a co-stimulatory/co-inhibitory molecule in the immune system to induce cellular immunity (Zhang and Hao 2019
). CD276 functions as an immune checkpoint protein induced on the surface of antigen-presenting cells and is important for inhibition of T cell function. This protein is overexpressed in a range of solid cancers and tumor-infiltrating blood vessels and frequently correlates with negative prognosis and poor clinical outcome (Picarda et al. 2017
). Anti-CD276 drug conjugates have been suggested as promising anti-cancer therapies, due to the overexpression of CD276 on tumors making it possible to distinguish between physiological and pathological processes (Seaman et al. 2018
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the C-terminus of human CD276
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to membrane
external side of plasma membrane
positive regulation of T cell proliferation
T cell activation
positive regulation of interferon-gamma biosynthetic process
regulation of immune response
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD276 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
How to Use the Spectraviewer
Watch the Tool Tutorial Video ▸
Start by selecting the application you are interested in, with the option to select an instrument from the drop down menu or create a customized instrument
Select the fluorophores or fluorescent proteins you want to include in your panel to check compatibility
Select the lasers and filters you wish to include
Select combined or multi-laser view to visualize the spectra