Rabbit anti CD23 antibody
recognizes low affinity immunoglobulin epsilon Fc receptor, also known as FCER2 and BLAST-2.
CD23 is a cell surface calcium-binding protein and receptor for the Fc domain of IgE, regulating synthesis of IgE on the surface of B lymphocytes and other cells (Jégouzo et al. 2019
). CD23 has been shown to act as a negative regulator for IgE and IgG antibody responses in B cells by influencing cellular activation and differentiation (Liu et al. 2016
). In addition CD23 regulates IgE-related immune responses by stimulating production of pro-inflammatory mediators (Rosenwasser and Meng 2005
). CD23 also facilitates induction of antibody and T-cell responses (Engeroff et al. 2020
). CD23 plays important roles in allergic disease through IgE-facilitated allergen presentation, controlling allergen-specific T-cell activation (Selb et al. 2017
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to residues near the C-terminus of human CD23
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to plasma membrane
positive regulation of nitric-oxide synthase activity
positive regulation of killing of cells of other organism
positive regulation of nitric-oxide synthase 2 biosynthetic process
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD23 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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