CD23 antibody | RM406

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Rabbit anti CD23

Product Type
Monoclonal Antibody
Clone
RM406
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6364
Datasheet
P WB
SDS
0.1 ml loader

Rabbit anti CD23 antibody recognizes low affinity immunoglobulin epsilon Fc receptor, also known as FCER2 and BLAST-2.

CD23 is a cell surface calcium-binding protein and receptor for the Fc domain of IgE, regulating synthesis of IgE on the surface of B lymphocytes and other cells (Jégouzo et al. 2019). CD23 has been shown to act as a negative regulator for IgE and IgG antibody responses in B cells by influencing cellular activation and differentiation (Liu et al. 2016). In addition CD23 regulates IgE-related immune responses by stimulating production of pro-inflammatory mediators (Rosenwasser and Meng 2005). CD23 also facilitates induction of antibody and T-cell responses (Engeroff et al. 2020). CD23 plays important roles in allergic disease through IgE-facilitated allergen presentation, controlling allergen-specific T-cell activation (Selb et al. 2017).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to residues near the C-terminus of human CD23

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
P06734
Entrez Gene
FCER2
GO Terms
GO:0005576 extracellular region
GO:0004872 receptor activity
GO:0005887 integral to plasma membrane
GO:0005178 integrin binding
GO:0005529 sugar binding
GO:0019863 IgE binding
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051712 positive regulation of killing of cells of other organism
GO:0051773 positive regulation of nitric-oxide synthase 2 biosynthetic process
Regulatory
For research purposes only

Applications of CD23 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/100 1/200
Western Blotting 1/500 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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