Rabbit anti CD140b antibody
recognizes platelet-derived growth factor receptor beta, also known as PDGFRB.
CD140b is a receptor tyrosine kinase expressed in many cell types and involved with a range of signaling pathways, including during embryonic development. CD140b plays an important role in vascular progenitor cell signaling (Karasozen et al. 2019
). Unusually for receptor tyrosine kinases, mutations in CD140b are only found in a few conditions with overlapping features (Pond et al. 2017
). However, overexpression of PDGFRB can occur in cancers. For example, PDGFRB has been found to be overexpressed but not somatically mutated in malignant pleural mesothelioma tissues. More broadly, PDGFRB is associated with aggressive behaviour of several tumor types (Melaiu et al. 2017
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the C-terminus of human CD140b
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
platelet activating factor receptor activity
platelet-derived growth factor beta-receptor activity
vascular endothelial growth factor receptor activity
integral to plasma membrane
platelet-derived growth factor receptor binding
positive regulation of cell proliferation
positive regulation of cell migration
platelet-derived growth factor binding
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD140b antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
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