CD140b antibody | RM303
Rabbit anti CD140b
- Product Type
- Monoclonal Antibody
- Clone
- RM303
- Isotype
- IgG
- Specificity
- CD140b
Antibody Quality and Performance Guarantee
| Rabbit anti CD140b antibody recognizes platelet-derived growth factor receptor beta, also known as PDGFRB. CD140b is a receptor tyrosine kinase expressed in many cell types and involved with a range of signaling pathways, including during embryonic development. CD140b plays an important role in vascular progenitor cell signaling (Karasozen et al. 2019). Unusually for receptor tyrosine kinases, mutations in CD140b are only found in a few conditions with overlapping features (Pond et al. 2017). However, overexpression of PDGFRB can occur in cancers. For example, PDGFRB has been found to be overexpressed but not somatically mutated in malignant pleural mesothelioma tissues. More broadly, PDGFRB is associated with aggressive behaviour of several tumor types (Melaiu et al. 2017). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the C-terminus of human CD140b
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/500 | 1/1000 |
| Western Blotting | |
1/250 | 1/500 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P09619
- Entrez Gene
- PDGFRB
- GO Terms
- GO:0004992 platelet activating factor receptor activity
- GO:0005019 platelet-derived growth factor beta-receptor activity
- GO:0005021 vascular endothelial growth factor receptor activity
- GO:0005887 integral to plasma membrane
- GO:0005161 platelet-derived growth factor receptor binding
- GO:0005524 ATP binding
- GO:0008284 positive regulation of cell proliferation
- GO:0018108 peptidyl-tyrosine phosphorylation
- GO:0030335 positive regulation of cell migration
- View More GO Terms
- GO:0046777 protein autophosphorylation
- GO:0048407 platelet-derived growth factor binding
- GO:0060326 cell chemotaxis
MCA6342
157605
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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