CD140b antibody | RM303

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Rabbit anti CD140b

Product Type
Monoclonal Antibody
Clone
RM303
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6342
Datasheet
P WB
SDS
0.1 ml loader

Rabbit anti CD140b antibody recognizes platelet-derived growth factor receptor beta, also known as PDGFRB.

CD140b is a receptor tyrosine kinase expressed in many cell types and involved with a range of signaling pathways, including during embryonic development. CD140b plays an important role in vascular progenitor cell signaling (Karasozen et al. 2019). Unusually for receptor tyrosine kinases, mutations in CD140b are only found in a few conditions with overlapping features (Pond et al. 2017). However, overexpression of PDGFRB can occur in cancers. For example, PDGFRB has been found to be overexpressed but not somatically mutated in malignant pleural mesothelioma tissues. More broadly, PDGFRB is associated with aggressive behaviour of several tumor types (Melaiu et al. 2017).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the C-terminus of human CD140b

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
P09619
Entrez Gene
PDGFRB
GO Terms
GO:0004992 platelet activating factor receptor activity
GO:0005019 platelet-derived growth factor beta-receptor activity
GO:0005021 vascular endothelial growth factor receptor activity
GO:0005887 integral to plasma membrane
GO:0005161 platelet-derived growth factor receptor binding
GO:0005524 ATP binding
GO:0008284 positive regulation of cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030335 positive regulation of cell migration
GO:0046777 protein autophosphorylation
GO:0048407 platelet-derived growth factor binding
GO:0060326 cell chemotaxis
Regulatory
For research purposes only

Applications of CD140b antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/500 1/1000
Western Blotting 1/250 1/500
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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