AKR1C1 antibody | CPTC4
Mouse anti AKR1C1
- Product Type
- PrecisionAb Monoclonal
- Clone
- CPTC4
- Isotype
- IgG1
- Format
- Purified
- Specificity
- AKR1C1
Antibody Quality and Performance Guarantee
| Mouse anti Human AKR1C1 antibody detects the aldo-keto reductase family 1 member C1, also known as 20-alpha-hydroxysteroid dehydrogenase (20-alpha-HSD), chlordecone reductase homolog HAKRC and high-affinity hepatic bile acid-binding protein (HBAB). Encoded by the AKR1C1 gene, aldo-keto reductase family 1 member C1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. Aldo-keto reductase family 1 member C1 catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. In the liver and intestine, it may have a role in the transport of bile, monitoring the intrahepatic bile acid concentration. Mouse anti Human AKR1C1 antibody detects a band of 36 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
|
- Target Species
- Human
- Western Blotting
- Anti AKR1C1 detects a band of approximately 36 kDa in A549 cell lysates.
- Product Form
- Purified IgG - liquid
- Preparation
- Mouse monoclonal antibody prepared by affinity chromatography on Protein G from tissue culture supernatant.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3).
- Immunogen
- Recombinant human AKR1C1
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml.
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunofluorescence |  |
||
| Western Blotting | |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- Q04828
- Entrez Gene
- AKR1C1
- GO Terms
- GO:0004033 aldo-keto reductase activity
- GO:0005829 cytosol
- GO:0055114 oxidation-reduction process
- GO:0006805 xenobiotic metabolic process
- GO:0046683 response to organophosphorus
- GO:0008206 bile acid metabolic process
- GO:0015721 bile acid and bile salt transport
- GO:0030299 intestinal cholesterol absorption
- GO:0032052 bile acid binding
- View More GO Terms
- GO:0042632 cholesterol homeostasis
- GO:0051260 protein homooligomerization
- GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
- GO:0047042 androsterone dehydrogenase (B-specific) activity
- GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
- GO:0047718 indanol dehydrogenase activity
VMA00334
151215
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