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Dupilumab antibody | AbD47092ia

Human anti Dupilumab

Product Type
Monoclonal Antibody
Clone
AbD47092ia
Isotype
IgG1
Specificity
Dupilumab

Product Code Applications Pack Size List Price Your Price Qty
HCA384
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SDS Safety Datasheet SDS
E 0.1 mg loader
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Human Anti-Dupilumab Antibody, clone AbD47092ia is a paratope specific, inhibitory anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody Dupilumab. HCA384 neither recognizes free IL-4Ra nor dupilumab in complex with IL-4Ra. Consequently, this antibody can be used to measure free dupilumab levels in serum from patients.

HCA384 may be used to develop and calibrate immune response assays to measure the anti-drug antibody (ADA) response in patient sera, together with HCA383.

Human Anti-Dupilumab Antibody, clone AbD47092ia is available as a monovalent Fab antibody incorporating a SpyTag under product code (TZA015) for conversion by the user into alternative antibody formats using any of the SpyCatchers available in our catalog.

Dupilumab (Dupixent) is a human IgG4/kappa antibody inhibiting both IL‐4 and IL-13 receptors, thereby blocking these receptor signaling pathways. Dupilumab inhibits the signaling of interleukins (IL) that induce inflammatory and immunological reactions in several atopic or allergic conditions, such as eczema, allergic reaction, and rhinosinusitis.

View a summary of all anti-dupilumab antibodies.

Product Form
Human IgG1 antibody (lambda light chain) selected from the HuCAL phage display library and expressed in a human cell line. This product is supplied as a liquid.
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Source
HKB-11
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Dupilumab
Affinity
The intrinsic affinity of the monovalent form of Human anti Dupilumab antibody, clone AbD47092ia is KD = 0.3 nM as measured by real time, label free molecular interaction analysis on immobilized Dupilumab.
Approx. Protein Concentrations
Antibody concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
Dupixent is a trademark of Regeneron Pharmaceuticals, Sanofi-Aventis.

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Technical Advice
Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
ELISA
Human anti Dupilumab antibody, clone AbD47092ia can be used as a calibrator in an anti-drug antibody assay.
Protocol: ADA bridging ELISA.

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Synonyms
Dupixent
Licensed Use
For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.

HCA384

164133

If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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