Dupilumab antibody | AbD47090ia
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E ResetHuman anti Dupilumab
- Product Type
- Monoclonal Antibody
- Clone
- AbD47090ia
- Isotype
- IgG1
- Specificity
- Dupilumab
Human Anti-Dupilumab Antibody, clone AbD47090ia is a paratope specific, inhibitory anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody Dupilumab. HCA383 neither recognizes free IL-4Ra nor dupilumab in complex with IL-4Ra. Consequently, this antibody can be used to measure free dupilumab levels in serum from patients. Human Anti-Dupilumab Antibody, clone AbD47090ia may be used to develop and calibrate immune response assays to measure the anti-drug antibody (ADA) response in patient sera, together with HCA384. Dupilumab (Dupixent) is a human IgG4/kappa antibody inhibiting both IL‐4 and IL-13 receptors, thereby blocking these receptor signaling pathways. Dupilumab inhibits the signaling of interleukins (IL) that induce inflammatory and immunological reactions in several atopic or allergic conditions, such as eczema, allergic reaction, and rhinosinusitis. View a summary of all anti-dupilumab antibodies. |
- Product Form
- Human IgG1 antibody (lambda light chain) selected from the HuCAL phage display library and expressed in a human cell line. This product is supplied as a liquid.
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Source
- HKB-11
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Dupilumab
- Affinity
- The intrinsic affinity of the monovalent form of Human anti Dupilumab antibody, clone AbD47090ia is KD = 0.4 nM as measured by real time, label free molecular interaction analysis on immobilized Dupilumab.
- Approx. Protein Concentrations
- Antibody concentration 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
Dupixent is a trademark of Regeneron Pharmaceuticals, Sanofi-Aventis. - Licensed Use
- For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA |
- Technical Advice
- Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
- ELISA
- Human anti Dupilumab antibody, clone AbD47090ia can be used as a calibrator in an anti-drug antibody assay.
Protocol: ADA bridging ELISA.
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Description | Human anti Dupilumab |
- Synonyms
- Dupixent
HCA383
164131If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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