Cemiplimab antibody | AbD41949ia
Human anti Cemiplimab
- Product Type
- Monoclonal Antibody
- Clone
- AbD41949ia
- Isotype
- IgG1
- Specificity
- Cemiplimab
Human Anti-Cemiplimab Antibody, clone AbD41949ia is a paratope specific, inhibitory anti-idiotypic antibody that specifically recognizes the fully human monoclonal antibody cemiplimab. It does not recognize free human programmed death receptor-1 (PD-1) nor cemiplimab in complex with PD-1. The antibody can be used to measure free cemiplimab in patient samples. Clone AbD41949ia is a fully human recombinant monoclonal antibody with IgG1 isotype and can be used as a surrogate positive control or reference standard in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 6 nM, and is one of three antibodies with different affinities offered for ADA assays. Cemiplimab (Libtayo) is a fully human IgG4/kappa antibody. It has been approved for the treatment of patients with metastatic cutaneous squamous cell carcinoma (CSCC) and for the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) whose tumours have high PD-L1 expression. Cemiplimab acts as a checkpoint inhibitor by binding to the PD-1 receptor and blocking its interaction with PD-L1 and PD-L2 ligands. View a summary of all anti-cemiplimab antibodies |
- Product Form
- Human IgG1 antibody (lambda light chain) selected from the HuCAL phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Source
- HKB-11
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Cemiplimab
- Affinity
- The intrinsic affinity of the monovalent form of Human anti Cemiplimab antibody, clone AbD41949ia is KD = 6 nM as measured by real time, label free molecular interaction analysis on immobilized Cemiplimab.
- Approx. Protein Concentrations
- Antibody concentration 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
Libtayo is a trademark of Regeneron Pharmaceuticals, Inc. - Licensed Use
- For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA |
- Technical Advice
- Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
- ELISA
- Human anti Cemiplimab antibody, clone AbD41949ia can be used as a calibrator in an anti-drug antibody assay.
Protocol: ADA bridging ELISA.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Hispec Assay Diluent | BUF049A | E IY | 50 ml | Log in | |||
List Price | Your Price | ||||||
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Description | Hispec Assay Diluent | ||||||
Human anti Cemiplimab | HCA368 | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Cemiplimab | ||||||
Human anti Cemiplimab | HCA369 | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Cemiplimab | ||||||
LYNX Rapid HRP Antibody Conjugation Kit | LNK002P | CJ | 3 Conjugations For 400µg Antibody | Log in | |||
List Price | Your Price | ||||||
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Description | LYNX Rapid HRP Antibody Conjugation Kit | ||||||
Human anti Cemiplimab | TZA006 | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Cemiplimab |
- Synonyms
- Libtayo
HCA367
160402If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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