IgM | Immunoglobulin M Class

Author: Misha Rahman, Ph.D.

Human IgM (immunoglobulin M)  is expressed on the surface of immature and mature B cells as monomers. IgM is the third most abundant human immunoglobulin.

IgM is also the first human immunoglobulin to be made by a fetus and virgin B cells which are challenged with antigen. IgM is a strong complement activator and agglutinator due to its pentameric structure and binds fragment crystallization (Fc) receptors.

IgM
Immunoglobulin M IgM

Heavy chain

μ

Light chain

κ or λ

Molecular formula

2κ2)5 or (μ2λ2)5

Valency

10

Structure

Pentamer

Abundance in serum (in relation to total immunoglobulins present)

6%

Carbohydrate content

12%

Concentration in serum

0.5 - 2.0 mg/ml

IgM subclasses

None

Heavy chain MW (kDa)

70

Light chain MW (kDa)

23

Total MW (kDa)

970

Distribution

Mainly intravascular

Function

Primary response antibody


Antibodies for Human IgM Isotype

Bio-Rad offers a range of human immunoglobulin antibodies for the IgM isotype. In addition to Human, we also offer IgM antibodies for the mouse specificity. Below you will find a list of all of our human and mouse IgM antibodies. Please use the filters to identify the antibody that fits your exact requirements.

IgM (Immunoglobulin M) Antibodies for Human and Mouse

    DescriptionSpecificityTargetFormatHostIsotypeClone Applications Citations Product Type Code

    Further Reading

    For a full overview of Immunoglobulin classes please visit our Immunoglobulins Classes / Sub-classes page. Alternatively you can view the following individual types: