IgE: Immunoglobulin E Class

Properties of IgE

Human immunoglobulin E (IgE) is expressed on the surface of mature B cells. Human immunoglobulin IgE is the least abundant Ig in the serum and does not activate the complement pathway.

Fragment crystallization (Fc) receptors for IgE are found on eosinophils and IgE binds Fc receptors on mast cells and basophils even before interacting with antigen. As a result of its binding to basophils and mast cells, IgE is involved in allergic reactions. This happens when allergen is bound to IgE on cells and releases various pharmacological mediators which cause allergies.

IgE
Heavy chain	ε
Light chain	κ or λ
Molecular formula	ε2κ2 or ε2λ2
Valency	2
Structure	Monomer
Abundance in serum (in relation to total immunoglobulins present)	0.002%
Carbohydrate content	12%
Concentration in serum	10 - 400 ng/ml
IgE subclasses	None
Heavy chain MW (kDa)	70
Light chain MW (kDa)	23
Total MW (kDa)	190
Distribution	Basophils and mast cells (in saliva and nasal secretions)
Function	Protects against parasites

IgE Antibodies

Bio-Rad offers a range of human immunoglobulin antibodies for the IgE isotype. In addition to human, we also offer IgE antibodies for a wide range of other target species. Below you will find a list of all of our IgE antibodies. Use the buttons/filters to identify the antibody that fits your exact requirements.

Related Reading

For a full overview of Immunoglobulin classes please visit our Immunoglobulins Classes / Sub-classes page. Alternatively you can view the following individual types:

• IgA Antibodies (Immunoglobulin A)
• IgD Antibodies (Immunoglobulin D)
• IgG Antibodies (Immunoglobulin G)
• IgM Antibodies (Immunoglobulin M)

Associated Secondary Antibody Reading

• Learn about Secondary Antibody Specific Binding Locations
• Secondary Antibodies - Learn how to optimize your experiments