IgE | Immunoglobulin E Class

Author: Misha Rahman, Ph.D.

H uman immunoglobulin E (IgE) is expressed on the surface of mature B cells. Human immunoglobulin IgE is the least abundant Ig in the serum and does not activate complement.

Fragment crystallization (Fc) receptors for IgE are found on eosinophils and IgE binds Fc receptors on mast cells and basophils even before interacting with antigen. As a result of its binding to basophils and mast cells, IgE is involved in allergic reactions. This happens when allergen is bound to IgE on cells and releases various pharmacological mediators which cause allergies.

IgE Immunoglobulin Class E: IgE

Heavy chain

ε

Light chain

κ or λ

Molecular formula

ε2κ2 or ε2λ2

Valency

2

Structure

Monomer

Abundance in serum (in relation to total immunoglobulins present)

0.002%

Carbohydrate content

12%

Concentration in serum

10 - 400 ng/ml

IgE subclasses

None

Heavy chain MW (kDa)

70

Light chain MW (kDa)

23

Total MW (kDa)

190

Distribution

Basophils and mast cells (in saliva and nasal secretions)

Function

Protects against parasites


Antibodies for Human IgE (Immunoglobulin E) Isotype

Bio-Rad offers a range of human immunoglobulin antibodies for the IgM isotype. In addition to human, we also offer IgE antibodies for the mouse specificity. Below are just a few of our products but feel free to use the search bar above to find a specific product.

Human and Mouse IgE Antibodies

    DescriptionSpecificityTargetFormatHostIsotypeClone Applications Citations Product Type Code