TIRAP antibody

Rabbit anti TIRAP

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
TIRAP

Product Code Applications Pack Size List Price Your Price Qty
AHP866
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SDS Safety Datasheet SDS
P * WB 0.1 mg loader
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loader
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Rabbit anti TIRAP antibody recognizes mouse toll-interleukin 1 receptor domain containing adaptor protein, also known as TIRAP, MyD88 adapter-like protein or Mal.

TIRAP is one of a family of TIR domain-containing proteins which serve as adaptor proteins for the Toll-like receptors during the innate immune response. TIRAP is reported to participate in the MyD88-dependent signaling pathways shared by TLR2 and TLR4.

Target Species
Mouse
Species Cross-Reactivity
Target SpeciesCross Reactivity
Human
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to mouse TIRAP were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide
Immunogen
Synthetic peptide corresponding to a region within the C-Terminus of mouse TIRAP.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1
Western Blotting 0.5ug/ml 2.0ug/ml
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

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Synonyms
MAL
RRID
AB_2205505
UniProt
Q99JY1
Entrez Gene
Tirap
GO Terms
GO:0004888 transmembrane receptor activity
GO:0005737 cytoplasm
GO:0006954 inflammatory response
GO:0007166 cell surface receptor linked signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB cascade
GO:0050830 defense response to Gram-positive bacterium
GO:0030099 myeloid cell differentiation
GO:0031224 intrinsic to membrane
GO:0032760 positive regulation of tumor necrosis factor production
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response
GO:0071221 cellular response to bacterial lipopeptide
GO:0071223 cellular response to lipoteichoic acid
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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