PPAR Delta antibody
No associated image currently available
Rabbit anti PPAR Delta (N-Terminal)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- PPAR Delta
- Region
- (N-TERMINAL)
Antibody Quality and Performance Guarantee
| Rabbit anti PPRAD antibody detects peroxisome proliferator-activated receptor, delta (PPARD), a member of the nuclear hormone receptor subfamily. Upon activation, PPARD forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARD controls genes involved in lipid metabolism, and enhances fatty acid catabolism and energy uncoupling in adipose tissue and skeletal muscle. PPARD has also been implicated in the proliferation and differentiation of preadipocytes, enterocytes, keratinocytes and the placenta. PPARD agonists could be used therapeutically to target multiple components of the metabolic syndrome, including insulin resistance, hyperglycemia, dyslipidemia, and atherosclerosis. |
- Target Species
- Mouse
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rabbit Expected from Sequence Chimpanzee Expected from Sequence Rat Expected from Sequence Human Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to PPAR delta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- Syntetic peptide corresponding to amino acids 1-14 of mouse PPAR delta.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1/30000 | 1/70000 |
| Western Blotting | |
1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- AHP1272 detects a band of approximately 55kDa in heart whole cell lysates.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
 |
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Sheep anti Rabbit IgG:FITC | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Sheep anti Rabbit IgG:RPE | ||||||
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml | Log in | |||
| List Price | Your Price | ||||||
| Log in | |||||||
| Description | TidyBlot Western Blot Detection Reagent:HRP | ||||||
Further Reading
-
Luquet, S. et al. (2005) Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes.
Biochim Biophys Acta. 1740 (2): 313-7. -
Barish, G.D. et al. (2006) PPAR delta: a dagger in the heart of the metabolic syndrome.
J Clin Invest. 116 (3): 590-7. -
Grimaldi, P.A. (2005) Regulatory role of peroxisome proliferator-activated receptor delta (PPAR delta) in muscle metabolism. A new target for metabolic syndrome treatment?
Biochimie. 87 (1): 5-8.
- Synonyms
- PPARD
- RRID
- AB_872033
- UniProt
- P35396
- Entrez Gene
- Ppard
- GO Terms
- GO:0000122 negative regulation of transcription from RNA polymerase II promoter
- GO:0001890 placenta development
- GO:0003707 steroid hormone receptor activity
- GO:0005634 nucleus
- GO:0006635 fatty acid beta-oxidation
- GO:0007566 embryo implantation
- GO:0050796 regulation of insulin secretion
- GO:0008047 enzyme activator activity
- GO:0008144 drug binding
- View More GO Terms
- GO:0008270 zinc ion binding
- GO:0008284 positive regulation of cell proliferation
- GO:0008366 axon ensheathment
- GO:0014068 positive regulation of phosphatidylinositol 3-kinase cascade
- GO:0015908 fatty acid transport
- GO:0016501 prostacyclin receptor activity
- GO:0016563 transcription activator activity
- GO:0016564 transcription repressor activity
- GO:0030154 cell differentiation
- GO:0031589 cell-substrate adhesion
- GO:0042060 wound healing
- GO:0042640 anagen
- GO:0043565 sequence-specific DNA binding
- GO:0043616 keratinocyte proliferation
- GO:0045598 regulation of fat cell differentiation
- GO:0046965 retinoid X receptor binding
- GO:0046982 protein heterodimerization activity
- GO:0050680 negative regulation of epithelial cell proliferation
- GO:0051546 keratinocyte migration
- GO:0060612 adipose tissue development
- GO:0070539 linoleic acid binding
AHP1272
150938
159165
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
View more products with PPAR specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
View all Anti-Mouse ProductsAlways be the first to know.
When we launch new products and resources to help you achieve more in the lab.
Yes, sign me up