IL-15 antibody

Rabbit anti Mouse Interleukin-15:Preservative Free

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
IL-15

Product Code Applications Pack Size List Price Your Price Qty
AHP2800Z
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E WB 0.1 mg loader
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loader
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Rabbit anti Mouse interleukin-15 antibody, recognizes interleukin-15 (IL-15), a four alpha helix member of the cytokine family of proteins. IL-15 elicits its biological function through a receptor complex composed of IL-2/IL-15 receptor beta. Upon binding of IL-15 to its receptor, the JAK, STAT, PI3K or MAPK signaling pathways can be activated (Robinson & Schluns 2017). This can result in the stimulation of T cell proliferation, generation of cytotoxic T lymphocytes, stimulation of immunoglobulin synthesis by B cells and the generation and persistence of natural killer cells (Steel et al. 2012).

Target Species
Mouse
Product Form
Purified IgG - lyophilized
Reconstitution
Reconstitute with 0.1 ml distilled water
Antiserum Preparation
Produced from sera of rabbits immunized with recombinant mouse interleukin-15 and purified by affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Carrier Free
Yes
Immunogen
E. coli derived recombinant mouse interleukin-15
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml after reconstitution
Endotoxin Level
< 0.1 ng/μg of protein (< 1 EU/μg)
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.

This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 0.5 ug/ml 2.0 ug/ml
Western Blotting 0.1 ug/ml 0.2 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P48346
Entrez Gene
Il15
GO Terms
GO:0001866 NK T cell proliferation
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005615 extracellular space
GO:0006955 immune response
GO:0048535 lymph node development
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0042102 positive regulation of T cell proliferation
GO:0045062 extrathymic T cell selection
GO:0045580 regulation of T cell differentiation
GO:0050691 regulation of defense response to virus by host
GO:0050778 positive regulation of immune response
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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