Rabbit anti Mouse interleukin-15 antibody,
recognizes interleukin-15 (IL-15), a four alpha helix member of the cytokine family of proteins.
IL-15 elicits its biological function through a receptor complex composed of IL-2/IL-15 receptor beta. Upon binding of IL-15 to its receptor, the JAK, STAT, PI3K or MAPK signaling pathways can be activated (Robinson & Schluns 2017
). This can result in the stimulation of T cell proliferation, generation of cytotoxic T lymphocytes, stimulation of immunoglobulin synthesis by B cells and the generation and persistence of natural killer cells (Steel et al. 2012
- Target Species
- Product Form
- Purified IgG - lyophilized
- Reconstitute with 0.1 ml distilled water
- Antiserum Preparation
- Produced from sera of rabbits immunized with recombinant mouse interleukin-15 and purified by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Carrier Free
- E. coli derived recombinant mouse interleukin-15
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml after reconstitution
- Endotoxin Level
- < 0.1 ng/μg of protein (< 1 EU/μg)
- Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
NK T cell proliferation
cytokine receptor binding
lymph node development
positive regulation of natural killer cell proliferation
positive regulation of natural killer cell differentiation
positive regulation of T cell proliferation
extrathymic T cell selection
regulation of T cell differentiation
regulation of defense response to virus by host
positive regulation of immune response
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of IL-15 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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