Rabbit anti TRAF2 antibody recognizes TNF receptor-associated factor 2 (TRAF2) also known as E3 ubiquitin-protein ligase TRAF2. TRAF2 belongs to the TNF receptor-associated factor (TRAF) family of proteins.
TRAF2 directly binds to TNF receptors and other TRAF proteins; playing a major role in TNF alpha mediated activation of MAPK8/JNK and NF-kappaB. TRAF2 forms a heterodimeric complex with TRAF1, and interacts with the IAP family members cIAP1 and cIAP2 functioning as a mediator of the anti-apoptotic signals from TNF receptors.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to TRAF2 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Recombinant human TRAF2
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
positive regulation of T cell cytokine production
ubiquitin-protein ligase activity
signal transducer activity
CD40 receptor binding
activation of caspase activity
activation of NF-kappaB-inducing kinase activity
zinc ion binding
induction of apoptosis by extracellular signals
activation of pro-apoptotic gene products
internal side of plasma membrane
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
CD40 receptor complex
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
protein K63-linked ubiquitination
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of TRAF2 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti TRAF2 antibody detects a band of approximately 56 kDa in cell lysates under reducing conditions
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Useful Reagents Available
How to Use the Spectraviewer?
Start by selecting the application you are interested in, with the option to select an instrument from the drop down menu or create a customized instrument
Select the fluorophores or fluorescent proteins you want to include in your panel to check compatibility
Select the lasers and filters you wish to include
Select combined or multi-laser view to visualize the spectra