Rabbit anti TRAF2 antibody recognizes TNF receptor-associated factor 2 (TRAF2) also known as E3 ubiquitin-protein ligase TRAF2. TRAF2 belongs to the TNF receptor-associated factor (TRAF) family of proteins.
TRAF2 directly binds to TNF receptors and other TRAF proteins; playing a major role in TNF alpha mediated activation of MAPK8/JNK and NF-kappaB. TRAF2 forms a heterodimeric complex with TRAF1, and interacts with the IAP family members cIAP1 and cIAP2 functioning as a mediator of the anti-apoptotic signals from TNF receptors.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to TRAF2 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Recombinant human TRAF2
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
positive regulation of T cell cytokine production
ubiquitin-protein ligase activity
signal transducer activity
CD40 receptor binding
activation of caspase activity
activation of NF-kappaB-inducing kinase activity
zinc ion binding
induction of apoptosis by extracellular signals
activation of pro-apoptotic gene products
internal side of plasma membrane
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
CD40 receptor complex
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
protein K63-linked ubiquitination
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of TRAF2 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti TRAF2 antibody detects a band of approximately 56 kDa in cell lysates under reducing conditions
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Secondary Antibodies Available
Useful Reagents Available