Goat anti OAS1 antibody
recognizes 2'-5'-oligoadenylate synthase 1 (OAS1), also known as E18/E16 and p46/p42 OAS.
OAS1 is a member of the OAS family of genes induced by interferons (IFN) and viruses, and appears to play a role in regulation of signaling pathways during viral infection (Lee et al. 2019
). The antiviral role of OAS1 appears to be attributed to its ability to detect short double stranded RNAs (dsRNAs) (Schwartz et al. 2020
). In addition to viral infections, OAS proteins have been implicated in autoimmune diseases and cancer. OAS1 can affect cell migration and high OAS1 mRNA expression has been linked to worse prognosis in patients with breast cancer (Zhang and Yu 2020
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human OAS1 were raised by repeated immunizations of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
0.5% Bovine Serum Albumin
- Peptide with sequence C-THEYPHFSHRPST, from the internal region (near C terminus) of the protein sequence according to NP_058132.2
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of OAS1 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Goat anti Human OAS1 antibody detects a band of approximately 50 kDa in cell lysates
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Secondary Antibodies Available
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